Hello,
We have been analysing genetic susceptibility to an experimentally-induced
disease in mice. The results are surprising.
Inbred strain A -100% susceptible;
inbred strain B -100% resistant.
(AxB)F1 - 50% are susceptible.
F2 - 25% are susceptible. So far, so good.
But 50% of the ((AxB)xA)BC1 mice develop disease.
(We don't have results for the reciprocal BC yet).
The problem is that the BC doesn't seem more susceptible than the F1.
Can anyone suggest a genetic model to explain these results? We haven't
been able to come up with one.
Any suggestions would be welcome.
-Grant
--
Grant Morahan, Ph.D.
The Walter and Eliza Hall Institute of Medical Research
Parkville, Victoria
AUSTRALIA
