Hello All,
I have been working with STRs on three families and have gotten some
interesting results. It appears we have found linkage with our gene of
interest and one locus. I am new at using the Linkage program and would like
some help. So far I have been able to input the data, and run some programs
(i.e., ILINK, MLINK) but I'm not sure how to interpurt the data. When I run
ILINK I get a LOD Score of 2.4 theata = 0.00. I know this is not sign. but
this is a small sample now. MLINK gives me the same value. So, I wanted to
test if the distances between two markers were correct (linked). I ran ILINK
and got a LOD of 0.6913 at theata of 0.3. When I ran MLINK, I got a LOD of
6.97 at theata max. 0.28. So, My question is why is there a 10 fold difference
in the values between ILINK and MLINK. BTW the distance between the markers is
29 cM.
Thanks in advance for any help.
Ronnie D. Jewell
