You may remember I posted this query a few days ago (if you don't
remember, you are probably not interested!).
Thanks for all your answers - the group is read by a lot more
people than you might suspect!
To remind you, when testing a disease against two closely-linked
(to each other) markers, using MLINK, I got:
1 (disease), 2 lod = 4.7
1, 3 lod = 2.7
1, 2, 3 lod = 16!
The consensus was (which makes perfect sense - I was simply ignorant)
that the third value is "Ott's generalized lod score", which is based
on the probability of ALL THREE LOCI BEING LINKED versus ALL 3 BEING
UNLINKED. And I know that 2 of them are linked.
So there you are! Thanks, folks
Mike Morris
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Division of Medical Genetics tel (Switzerland) (22) 702.56.94
CMU, University of Geneva fax (Switzerland) (22) 702.57.06
Geneva, Switzerland email mike at medsun.unige.ch
