> What is the influence of having allele frequencies not add up to 1, eg. when
> some alleles are not present in a pedigree under study. What is the best
> approach to this kind of problem?
Best approach is to specify n+1 alleles, where there are n alleles
actually observed in the pedigree. Use the correct allele frequencies
for the n alleles, and for the n+1th allele, use 1 minus the sum of
the frequencies of the observed alleles.
Ellen Wijsman
Div of Medical Genetics, RG-25
and Dept of Biostatistics
University of Washington
Seattle, WA 98195
wijsman at u.washington.edu
