IUBio

Linkage proble

Iain Fenton WMGIF at CARDIFF.AC.UK
Tue Dec 20 05:28:04 EST 1994


hi lucien !

> I have a strange mlink problem.

don't we all.

> The analysis is a dominant disease in a 7 seven generations pedigree 
> with 171 individuals and one loop. 
> All files have been checked and look correct.
> The results are always -infinity for all thetas,

i would guess that something is wrong in the DATAFILE, particularly if 
UNKNOWN is happy, that would suggest that the PEDFILE is ok.  if it is only 
one family, albeit an *enormous* family  :-)   can you post the PEDFILE & 
DATAFILE to this list so that we can play with them ?  you could think of 
it as an early christmas present to us !!

:-)  :-)  :-)  :-)

oh, and happy christmas lucien !

Iain Fenton, Cardiff, UK.



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