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New way to visualize specific proteins in living cells using fluorescence

A. S. Goustin Lab hivlab at CMB.BIOSCI.WAYNE.EDU
Wed Feb 24 13:45:00 EST 1999


Last year, Roger Tsien has described a new approach to a fluorescent
vital dye for specific proteins.  It involves tagging the protein with a
small tag which then serves as a target for a fluorescent pro-ligand:

     4',5'-bis(1,3, 2- dithioarsolan-2-yl)fluorescein

Griffin BA, Adams SR & Tsien RY.  (1998).  Specific covalent labeling of
   recombinant protein molecules inside live cells.  Science 281, 269-272.

Has anybody had luck with this new approach?






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