2 Post-doc positions (3 years, respectively) are available in the
research group of Annette Schenck at the Department of Human Genetics at
the Nijmegen Centre of Molecular Life Science (NCMLS) - Donders
Institute for Brain, Cognition and Behaviour - Radboud University
Nijmegen Medical Centre in Nijmegen, the Netherlands. The Department of
Human Genetics in Nijmegen is a world-leading place for research into
genetic forms of brain disorders, where clinical research, disease gene
identification and functional studies work hand in hand. Using disease
genes as an entry point and Drosophila as a primary research tool, the
group of Annette Schenck dissects gene function, molecular networks and
mechanisms that underlie brain development and cognition and aims to
translate this knowledge back to humans.
Project 1 (Job Ad #010137):
Project 1, funded through the European Union's large-scale FP7 network
GenCoDys (Genetic and Epigenetic Networks in Cognitive Dysfunction),
aims to systematically elucidate the function of genes implicated human
Mental Retardation Disorder. More than 300 genes are conserved in fly
and can be characterised for their role in non-associative learning
using RNAi and an innovative high-throughput semi-automated system to
measure jump-reflex habituation (in collaboration with Dr. Z.
Asztalos/Aktogen Ltd, Cambridge, consortium member). The lab, department
and FP7 consortium offer great opportunities to follow up on the most
interesting phenotypes and genes, e.g. by structural nervous system
analyses, by dissection of associated signalling pathways or
identification of transcriptional targets, and by the identification of
genetic or chemical modifiers that alleviate learning or other defects.
The goal of our large scale research is to identify novel molecular
networks that provide conceptual advance in our understanding of brain
development in health and disease. We also aim to significantly
contribute to the development of novel diagnostic and therapeutic
strategies for the large and still growing group of MR disorders.
GenCoDys partners of the Drosophila work package are A. Schenck (WP
leader); K. Keleman/B.J. Dickson (Vienna); P. Tomancak (Dresden); Z.
Asztalos/Aktogen Ltd (Cambridge); Network coordinator: H. van Bokhoven
Project 2 (Job Ad #010136):
ADHD is a highly heritable and genetically complex disorder. Genome-wide
association studies (GWAS) have implicated a series of genes, yet their
function is poorly understood and proof that these genes regulate
neuronal development and function relevant to ADHD is, in most cases,
missing. This project, funded through the NWO Brain & Cognition
Excellence programme, strives to collect this proof for a selection of
published and unpublished ADHD genes and to unravel the role of these
genes in different aspects of neuronal development, function and in
relevant animal behaviours such as activity, learning and memory.
Genes will be initially investigated using available
genome-wide resources for gene manipulation and assays that are
established in the host laboratory. The labs, department and
collaborators offer great opportunities to follow up on the most
interesting genes/phenotypes in flies and humans, e.g. by dissection of
associated signalling pathways, by the identification of genetic or
chemical modifiers that alleviate determined fly phenotypes, and by
translating findings back to the human situation using neuroimaging
techniques and neurocognitive testing in conjunction with association
and mutation testing in exceptionally large patient samples (performed
by others but involvement is possible).
The project will be carried out in a close collaboration
with the lab of Barbara Franke. She heads the International Multicenter
persistent ADHD CollaboraTion (IMpACT), a consortium of 5 European, 2 US
and 1 Brazilian groups, which has extensive phenotypic and genetic data
of more than 3000 adult ADHD patients, the largest clinical ADHD sample
available worldwide. It aims to advance our understanding of the
Genetics and Neurobiology of ADHD. We are particularly interested in the
arising concept that ADHD results from neuronal connectivity defects and
in the genetic and neurobiological overlap with other cognitive
disorders such as mental retardation and autism that we investigate in
* A PhD in a domain of Molecular Life Sciences * Strong background in
Drosophila genetics, and ideally in neurobiology, good knowledge in
molecular and cell biology * high affinity for fundamental research
related to human disease * Highly motivated, with excellent
interpersonal and communication skills and with the strong wish to work
Enthusiastic, creative and interactive researchers that meet these
demands are encouraged to apply or contact us for further information.
Selected Publications: (1) Anitei, M. et al. Nat Cell Biol, 2010,
12(4):330-40; (2) Zweier, C. et al. Am J Human Genetics, 2009; (3)
Schenck, A. et al. Cell, 2008, 133: 486-497; (4) Qurashi, A. et al.
Neural Development, 2007, 2: 18; (5) Kim et al. Nature, 2006, 442:814-7;
(6) Schenck, A. et al. Dev Biol, 2004, 274 : 260-70; (7) Schenck, A. et
al. Neuron, 2003, 38: 887-98.
Nijmegen: Nijmegen, located about 100 km from Amsterdam near the German
border, is the Netherlands' oldest city. It offers historic sites and
museums, borders beautiful forest countryside and polder landscapes and
hosts one of the Netherland's most successful universities with a
particular emphasis on biomedical research and Neuroscience.
Send your application including a letter of motivation, CV and two
letters of recommendation to Dr. Annette Schenck, E-mail:
a.schenck from antrg.umcn.nl. Closing date is October, 1st 2010. Please
indicate "Dros ad" and project/job ad number in the subject line of the
e-mail. Only complete application documents will be considered.
Annette Schenck, PhD|Associate Professor|Department of Human Genetics
(855)|Nijmegen Centre for Molecular Life Sciences|Donders Institute for
Brain, Cognition and Behaviour|Radboud University Nijmegen Medical
Centre|Geert Grooteplein 10|6525 GA Nijmegen|the Netherlands|tel:
+31-24-3617431|secretary: +31-24-3614017|fax: +31-24-3668752|mailto:
a.schenck from antrg.umcn.nl|For more information visit
Het UMC St Radboud staat geregistreerd bij de Kamer van Koophandel in het handelsregister onder nummer 41055629.
The Radboud University Nijmegen Medical Centre is listed in the Commercial Register of the Chamber of Commerce under file number 41055629.