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[Drosophila] Confused about translocation T(2;4)

Kevin Cook kcook at bio.indiana.edu
Thu Nov 10 13:16:51 EST 2005


Karmella--

T(2;4)ast[v] consists of two parts.  One "half" of the translocation 
has the second chromosome centromere and the other has the fourth 
chromosome centromere.  Shown pictorially, the two chromosomes are

2Lt--------21E2|101--------4cen----4Lt

4Rt------101|21E3-------2cen-----------2Rt

Where "2Lt" denotes the telomere of 2L, "4Rt" denotes the telomere of 
4R, etc.  (Believe it or not, there really is a tiny left arm of the 
4th chromosome!)  Each "half" of a translocation is called a 
translocation segregant and the "halves" of T(2;4)ast[v] shown above 
are called Ts(2Lt;4Lt)ast[v] and Ts(2Rt;4Rt)ast[v], respectively.

In the stock, Ts(2Rt;4Rt)ast[v] segregates from the In(2L)Cy, 
In(2R)Cy, al[2] Cy[1] L[4] sp[2] chromosome and
Ts(2Lt;4Lt)ast[v] segregates from a normal 4th chromosome, based on 
the homology of the centromeric regions.  The stock genotype could be 
rewritten as

Ts(2Rt;4Rt)ast[v]/In(2L)Cy, In(2R)Cy, al[2] Cy[1] L[4] sp[2]; 
Ts(2Lt;4Lt)ast[v]/+

Hope this helps,
Kevin

__________________________________________________________
Kevin Cook, Ph.D.               Bloomington Drosophila Stock Center
Department of Biology           http://flystocks.bio.indiana.edu
Jordan Hall 142
Indiana University              812-856-1213
1001 E. Third St.               812-855-2577 (fax)
Bloomington, IN  47405-7005     kcook at bio.indiana.edu 



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