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[Drosophila] Confused about translocation T(2;4)

Kevin Cook kcook at bio.indiana.edu
Thu Nov 10 13:16:51 EST 2005


T(2;4)ast[v] consists of two parts.  One "half" of the translocation 
has the second chromosome centromere and the other has the fourth 
chromosome centromere.  Shown pictorially, the two chromosomes are



Where "2Lt" denotes the telomere of 2L, "4Rt" denotes the telomere of 
4R, etc.  (Believe it or not, there really is a tiny left arm of the 
4th chromosome!)  Each "half" of a translocation is called a 
translocation segregant and the "halves" of T(2;4)ast[v] shown above 
are called Ts(2Lt;4Lt)ast[v] and Ts(2Rt;4Rt)ast[v], respectively.

In the stock, Ts(2Rt;4Rt)ast[v] segregates from the In(2L)Cy, 
In(2R)Cy, al[2] Cy[1] L[4] sp[2] chromosome and
Ts(2Lt;4Lt)ast[v] segregates from a normal 4th chromosome, based on 
the homology of the centromeric regions.  The stock genotype could be 
rewritten as

Ts(2Rt;4Rt)ast[v]/In(2L)Cy, In(2R)Cy, al[2] Cy[1] L[4] sp[2]; 

Hope this helps,

Kevin Cook, Ph.D.               Bloomington Drosophila Stock Center
Department of Biology           http://flystocks.bio.indiana.edu
Jordan Hall 142
Indiana University              812-856-1213
1001 E. Third St.               812-855-2577 (fax)
Bloomington, IN  47405-7005     kcook at bio.indiana.edu 

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