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Post-doc/tech positions

Kim McKim mckim at rci.rutgers.edu
Fri Nov 8 17:10:07 EST 2002

Positions Open for Research on the Molecular Genetics of Meiotic 

My laboratory currently has two positions open for a technician or a 
post-doctoral fellow.  We are looking for energetic scientists with an 
interest in applying genetic techniques towards understanding an 
important biological process.  More specifically, we use molecular, 
genetic and cytological techniques to study and understand the genes 
required for meiotic recombination and chromosome segregation in 
Drosophila melanogaster females. 

email Dr. McKim for details.

Lab web site:  waksman.rutgers.edu/~mckim

The objective of the research in my laboratory is to understand how the 
genetic information of the parent is segregated into the reproductive 
cells or gametes.  Central to this process is meiosis, where the 
chromosome complement of the parent is divided in half and packaged into 
either a sperm or oocyte.  This process must be precise, because if the 
gamete receives abnormal numbers of chromosomes, the result is 
aneuploidy in the fertilized cell and usually death of the developing 
embryo.  In certain cases, these aneuploids survive in humans, resulting 
in syndromes such as Down's, Turner's and Klinefelter's.  But in most 
cases the aneuploids are lethal and in humans are the leading cause of 
infertility and spontaneous abortions in women.  This research has far 
reaching applications.  For example, errors during meiosis lead to 
decreased fertility in humans.  In addition, understanding defects in 
recombination and DNA repair have implications for many forms of 
cancer.  Many of the genes with a role in meiosis also function in 
somatic cells for DNA metabolism and repair. 

Kim S. McKim, Ph.D.
Waksman Institute and Department of Genetics
Rutgers University
190 Frelinghuysen RD
Piscataway NJ  08854
(732) 445 1164
mckim at rci.rutgers.edu

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