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Two postdoc positions are available in Cambrdige, UK.

Kazuya Usui ku204 at hermes.cam.ac.uk
Mon Jul 9 11:08:24 EST 2001

Two postdoc positions are available in Cambrdige, UK.

Two Wellcome-Trust-funded postdoctoral positions are available in the
Zoology Department of the University of Cambridge, UK, to join Pat
Simpson's group (email: pas49 at hermes.cam.ac.uk).

The group project concerns the Development and Evolution
of bristle patterns in Diptera. Changes in gene regulation during
development are responsible for many of the morphological differences
underlying animal diversity.

We are using the bristle patterns in different species of flies
as a model to investigate changes in regulation of genes
of the achaete-scute family.

In Drosophila the stereotyped bristle pattern results from complex
spatio-temporal regulation of achaete-scute, mediated
by a number of discrete cis-regulatory sequences and spatially restricted
upstream transcriptional regulators. Differences in the positioning of
bristles in other species are linked to changes in the spatial expression
of scute homologues. We are currently attempting to isolate and identify
regulatory elements from Calliphora vicina and Anopheles gambiae.

Applicants should have a background in either molecular or developmental
biology (experience with insect transgenesis or the use of RNAi would be 

Selected literature:
Simpson, P., Woehl, R.and Usui, K. 1999. Development 126:1349-1364.
Gomez-Skarmeta, J. L., Rodriguez, I., Martinez, C., Culi, J., Ferres-Marco, D.,
Beamonte, D. and Modolell, J. 1995 Genes Dev 9, 1869-1882.
Garcia-Garcia, M-J., Ramain, P., Simpson, P. and Modolell, J. 1999 
Development, 126:
Wubeck, C. and Simpson, P. 2000 Development 127: 1411-1420.
Skaer, N. and Simpson, P. 2000  Developmental Biology 221: 148

Dr. Pat Simpson, FRS
Department of Zoology,
Downing Street,
Cambridge CB2 3EJ,

Tel: 00 44 1223 33 66 64 (lab)
Tel: 00 44 1223 33 66 69 (office)
Fax: 00 44 1223 33 66 76
email: pas49 at hermes.cam.ac.uk
Kazuya Usui (Ph. D)
Department of Zoology
University of Cambridge
Downing Street
Cambridge CB2 3EJ
Email: ku204 at hermes.cam.ac.uk
Tel: +44.(0)1223.33.66.64
Fax: +44.(0)1223.33.66.76
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