Apply your fly skills to the study of mammalian disease!
Our laboratory studies the cell and molecular biology of pigmentation in
the eyes and skin of mammals. A postdoctoral position is available for a
recent Ph.D. graduate to study the roles of mouse/human homologues of genes
controlling the trafficking to and biogenesis of Drosophila pigment
granules. Mutations in several of these genes cause oculocutaneous albinism
(visual defects and predsiposition to skin cancers), while others in
addition cause multisystem diseases with immunodeficiency and bleeding
disorders due to a common biogenetic pathway with endolysosomal organelles.
Facility with common cellular and molecular techniques is expected.
Experience with immunomicroscopy or EM would be an added bonus.
Funding is available for 3-4 years. NYU is an equal opportunity employer.
Some recent lab publications:
1.Orlow SJ, Brilliant MH. The pink-eyed dilution locus controls the
biogenesis of melanosomes and levels of melanosomal proteins in the eye.
Exp Eye Res (1999) 68:147-154.
2.Samaraweera P, Donatien PD, Qazi S, Kobayashi T, Hearing VJ, Panthier JJ,
Orlow SJ. Identification and characterization of a melanocyte-specific
novel 65 kDa peripheral membrane protein. Eur J Biochem (1999) 266:
3.Pawelek JM, Chakraborty AK, Rachkovsky ML, Orlow SJ, Bolognia JL, Sodi
SA. Altered N glycosylation in macrophagexmelanoma fusion hybrids. Cell
Mol Biol (1999) 45: 1011-1027.
4.Manga P, Sato K, Beermann F, Lamoreux ML, Hearing VJ, Orlow SJ.
Mutational analysis of the modulation of tyrosinase by tyrosinase-related
proteins 1 and 2. Pigment Cell Res (2000) 13: 364-374.
5.Samaraweera P, Newton J, Barsh GS, Orlow SJ. The mouse ocular albinism 1
gene product is an endolysosomal protein. Exp Eye Res (2001) 72: In press.
6.Shen B, Rosenberg B, Orlow SJ. Intracellular distribution and late
endosomal effects of the ocular albinism 1 gene product: consequences of
disease-causing mutations and implications for melanosomal biogenesis.
Traffic (2001) 2: In press.
If interested, please submit cover letter, CV and names/contact info for 3
Seth J. Orlow, M.D., Ph.D.
Professor of Cell Biology & Dermatology
NYU School of Medicine
560 First Avenue, Room H-100
New York, NY 10016
email seth.orlow at med.nyu.edu