Postdoctoral Position Available:
Drosophila Tracheal Development at Northwestern university
Lab: Dr. Greg Beitel, BMBCB Hogan Hall Rm. 2-100, Northwestern
University, Evanston IL 60208-3500; (847) 467-7776, beitel at northwestern.edu
My laboratory's long term goal is to understand how individual
cells control their shapes and coordinate with other cells to create the
complex organs found in multicellular organisms. To this end, we are using
genetic, molecular and cell biological approaches to identify and study
genes required for the morphogenesis of the Drosophila tracheal system.
The Drosophila tracheal system is a ramifying network of epithelial tubes
that serves as a combined airway and vascular system for delivering oxygen
to tissues in the fly. At the molecular level, Drosophila tracheal
development has striking similarities to both vertebrate lung and vascular
development. These similarities, coupled with the simplicity of the
tracheal system and the power of Drosophila genetics, makes the tracheal
system an outstanding model system for understanding the morphogenesis of
the tubular epithelia that are central to such vertebrate organs as the
vascular system, lung and kidney.
We have shown that size of the Drosophila tracheal tubes is
controlled by a genetic program and identified mutations in eight genes
that cause the tracheal tubes to have abnormal lengths or diameters. We
have also identified mutations that affect cell-cell adhesion and the
apical/basal organization of tracheal cells. We are currently cloning and
characterizing several of these genes, and will pursue the vertebrate
homologues of these genes to understand the general roles of these genes in
the morphogenesis of tubular epithelial organs.
Dr. Greg Beitel, Assistant Professor
Dept. of Biochemistry, Molecular Biology and Cell Biology (BMBCB)
Hogan Hall, Rm. 2-100
2153 North Campus Dr.
Evanston, IL 60208-3500
Phone: (847) 467-7776
FAX: (847) 467-1380