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Multinucleated phenotypes.. causes?

G. Dellaire, Ph.D G.Dellaire at hgu.mrc.ac.uk
Tue Jun 8 02:47:12 EST 1999

I have a cell line with a peculiar multinucleated/micronucleated
phenotype.  Does anyone know of some of the mutant proteins or disrupted
pathways that may be involved in producing such a phenotype?  So far,
most of the literature I have found points to disruption of microtubules
and proteins involved in regulating the contractile ring function during
cytokinesis. If you have read or know of any other causes please post
here or to my e-mail.


Graham Dellaire
Graham Dellaire, Ph.D.

MRC Human Genetics Unit
Western General Hospital
Crewe Road
Edinburgh, UK

Fax: +44 (0)131 343 2620
Phone: +44 (0)131 332 2471

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