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Genome Sequence

T. Kaufman kaufman at bio.indiana.edu
Thu Dec 2 08:54:38 EST 1999


Dear Fly Person,

I am writing  as President of the National Drosophila Board to inform you
about the current status of the Drosophila genome sequencing project.
During the early part of November, representatives of BDGP, EDGP, FlyBase,
other members of the Drosophila community, and several experts in
bio-informatics met at Celera, in Rockville, MD.  The goals were to 1)
integrate the Celera 10X shotgun sequence assembly with the BDGP/EDGP
sequence and maps, 2) annotate the sequence, most notably identify all the
known transcripts and ORFs, and 3) begin to analyze the sequence for
information about chromosome organization and gene content.  This was an
unusual merger of academics and industry, which led to a remarkable and
productive synergy, thanks to the organization and efforts of Mark Adams
(Celera) and Gerry Rubin (BDGP) and the intensive work and commitment
displayed by all participants.  The jobs are not yet complete, but we can
report that the sequence and the assembly are of very high quality, and that
the tools are in place to perform a more complete analysis in the next
couple of months.  Much of the unannotated sequence resulting from Celera's
assembly of its whole genome shotgun data has already been deposited in
GenBank, and the rest will be in GenBank by the end of the year.  Likewise,
all the BDGP and EDGP data are currently in GenBank.  The combined
BDGP/EDGP/Celera assembled and annotated sequence will be released upon
publication, as early as February 2000. You will be very pleased with the
results, and excited by the new avenues of exploration that will be
facilitated by this information.  We are about to enter a new and exciting
time for all Drosophila biologists, and should embrace the future without
forgetting that an incredible century of Drosophila genetics and biology
brought us to this point.

Gary

Thom Kaufman   	     	       kaufman at sunflower.bio.indiana.edu
--- Department of Biology, HHMI --- Indiana University
--- Jordan Hall 142 --- 1001 East Third Street --- Bloomington, IN 47405
--- 812-855-3033/Office --- 812-855-7674/Lab --- 812-855-2577/FAX





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