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Postdoctoral Position

Jim Birchler birchler at BIOSCI.MBP.MISSOURI.EDU
Tue Aug 4 22:13:46 EST 1998

available in the spring of 1999 to study dosage compensation and dosage
sensitive regulatory genes in Drosophila. The successful applicant will
study Drosophila orthologues of the yeast NOT global negative regulatory
complex. A mutation in one component of the complex was originally
identified by its negative dosage effect on the expression of the white eye
color gene (see Frolov et al., 1998, Genetics 148: 317-329). Extensive data
in yeast and preliminary data from Drosophila indicate a specificity of the
complex for TATAless promoters. Genes with TATAless promoters are strongly
overrepresented on the X chromosome (I. Arkhipova, Abstract, 35th
Drosophila Research Conference), suggesting a potential involvement of this
complex with the dosage compensation of several X linked genes. Experience
with genetics/molecular biology and good communication skills are
desirable. Interested individuals should send curriculum vitae and the
names, addresses and phone numbers of three references to: James Birchler,
Division of Biological Sciences, Tucker Hall, University of Missouri,
Columbia, MO 65211-7400; Email: birchler at biosci.mbp.missouri.edu . The
University of Missouri is an Affirmative Action/Equal Opportunity Employer.
James A. Birchler
Professor of Biological Sciences
University of Missouri
117 Tucker Hall
Columbia, MO 65211
(573) 882-4905 (voice)
(573) 882-0123 (FAX)

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