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job offer

ralf stanewsky stanewsky at BINAH.CC.BRANDEIS.EDU
Fri Apr 3 13:41:28 EST 1998

Two Ph.D. positions are available for students interested in studying
circadian rhythms in Drosophila melanogaster. Projects involve
molecular-genetic analyses of novel circadian rhythm mutants, including
cloning and expression studies of the relevant genes as well as behavioral
studies. Mutants were isolated in two screens using a real-time
bioluminescence reporter gene (luciferase) allowing direct measurement of
rhythmic gene-expression in living flies. The first screen (EMS) resulted in
the identification of mutations that effect rhythmic expression of the known
clock genes PERIOD and TIMELESS and therefore seem to fulfill a crucial
function in circadian time-keeping. The second (enhancer-trap) screen
allowed the generation of multiple independent P-element insertion lines
showing rhythmic expression of the luciferase cDNA due to an insertion near
a circadianly regulated enhancer. Isolation and disruption of the
corresponding rhythmically expressed gene(s) should reveal their function in
the circadian system. The novel strategy of both screens will allow it to
identify components of all three levels of the circadian system (input,
pacemaker, output).

The project is funded by a 3 year (up to 5) DFG (Deutsche
Forschungsgemeinschaft) Grant "Nachwuchsgruppen in den Biowissenschaften"
awarded to Ralf Stanewsky and starts on September 1, 1998. The group will be
located at the University of Regensburg, Department of Developmental Biology
(Prof. Dr. Stephan Schneuwly), Germany (Bavaria). Non-German applicants
should have a degree similar or equivalent to the German Diploma in Biology
(for example a masters degree), but other students can also apply.
Interested candidates should contact Dr. Ralf Stanewsky immediately. Please
send two letters of recommendation to:

Dr. Ralf Stanewsky
Department of Biology
Brandeis University
Mailstop 008
Waltham, MA 02254
Tel.: 001-781-736-3174
FAX: 001-781-736-3107
e-mail: Stanewsky at brandeis.edu

Ralf Stanewsky                            
Department of Biology
Brandeis University
Mailstop 008
Waltham, MA 02254

Phone: (781)736-3174
FAX:   (781)736-3107

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