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[Computational-biology] Call for submissions on hypothetical and uncharacterized protein research: IWBBIO 2014@Spain

Prash via comp-bio%40net.bio.net (by prash from bioclues.org)
Thu Dec 5 07:38:52 EST 2013


Details at http://iwbbio.ugr.es/sessions_proposals.php
*SS17**Annotation and Curation of Uncharacterized Proteins: Systems Biology
Approaches*

A hypothetical protein (HPs) is a protein whose existence is predicted but
whether or not it is expressed remains uncertain. However, many HPs in the
recent past have been known to be expressed in vivo. With various methods
known to identify components in cell membrane, the functional significance
of thousands of proteins especially those that do not have function, not
expressed, unique or common among genomes is least understood. Apart from
this, many HPs might turn out to be pseudogenes at a later point of time
and the use of these proteins remain mis-conducive. To circumvent the
problem, several methods to easily screen functional candidates among many
hypothetical proteins, use of feature selection algorithms and testing the
efficacy of these proteins in terms of precision and accuracy using
stochases have widely been covered. With experimental procedures for HP
function prediction being low throughput by nature, there has been a need
to precisely know their functions for a better understanding of the
underlying biological mechanism. We would invite authors interested in
these niche areas of annotating uncharacterized proteins and functional
genomics for their contribution in any of the following areas, not just
limited to the following but to a broader purview:

   - Computational flow for the functional annotation of uncharacterized
   proteins using motif discovery, sequence and structural similarity,
   structural homology, hypothome (interactome of hypothetical proteins) or
   combination of data from highly similar non-interacting proteins
   (Similactors).
   - Predictive approaches based on Gene Ontology (GO).
   - Feature selection and machine learning methods.
   - Diseasome approaches.


*Organizers: Prof. Alfredo Benso <alfredo.benso from polito.it>*, Department of
Control and Computer Engineering, Politecnico di Torino (Italy)

*Dr. Prashanth Suravajhala <prash from bioclues.org>*, Founder of Bioclues.org
and Director of Bioinformatics.org

 Prashanth Suravajhala, PhD.
Homepage: http://www.bioinformatics.org/wiki/Prash
<http://www.bioinformatics.org/wiki/Prash>


Linkedin: http://dk.linkedin.com/in/prashbio

 "Scientific research is one of the most exciting and rewarding of
occupations." ~Frederick Sanger


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