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Ends of sequence critical to tertiary structure too?

Adrian AdrnLgrvtn at gazeta.pl
Fri Sep 20 20:13:16 EST 2002


You know amino acid sequence probably totally determines into what tertiary
structure the protein folds. Also it is well known the crucial one could be
change on just one position in a sequence, eg. of 400 elements.

The question: are the amino acids postioned near very ends of sequences also
so critical for the process of folding? What will it happen if a sequence is
slightly shortened by removing 1 or 2 aminoacids from sequence's ends? (Or
if very end is altered by exchanging an aminoacid?) Will the tertiary
structure change significantly?

Thank You in advance for any help!

Adrian




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