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postdoctoral position

Tue Aug 10 16:03:18 EST 1993


      A postdoctoral position will be available in the Witman lab for the study 
of Chlamydomonas outer arm dynein using a combination of genetic, molecular 
genetic, and cell biological approaches.  Possible projects include:
a) cloning of tagged genes that affect outer arm function or assembly.  The 
mutants already have been generated and are ready to begin work on.
b) cloning and analysis of outer arm dynein light chains.  Partial direct amino 
acid sequence data already has been obtained and could be used to isolate cDNAs 
by oligonucleotide screening or PCR-based techniques.
c) analysis of the force-generating properties of individual outer arm dynein 
subunits using video-enhanced DIC microscopy.  The combination of mutants 
lacking specific subunits of the outer arm and of new techniques for 
purification of dynein subunits should greatly facilitate this project.
d) determination of the locations of different inner arm dynein heavy chains 
along the flagellar axoneme.  Partial cDNA clones encoding several inner arm 
dynein heavy chains are available and have been sequenced; this data could be 
used to design specific anti-peptide antibodies for localization studies.
      The Worcester Foundation for Experimental Biology offers excellent 
facilities and a stimulating environment for postdoctoral study.  The 
Foundation is a private, non-profit research institute, located on a 75-acre 
campus in Shrewsbury, Massachusetts.
      Starting date for this position is flexible but ideally would be sometime 
in the fall of 1993.  If interested please contact George Witman by phone (508) 
842-8921 ex. 344, FAX (508) 842-3915, email Witman at sci.wfeb.edu, or mail at
Worcester Foundation for Experimental Biology, 222 Maple Avenue, Shrewsbury, MA
01545 USA.

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