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Announcement of new database - InterPro

Alexander Kanapin alex at ebi.ac.uk
Fri Nov 26 05:41:35 EST 1999


 InterPro is an Integrated Resource of Protein Domains
 and Functional Sites. InterPro rationalises the complementary
 efforts of the PROSITE, PRINTS, Pfam and ProDom database projects.
 Merged annotations from PRINTS, PROSITE and Pfam form the InterPro
 Each combined InterPro entry includes functional descriptions and
 literature references, and links are made back to the relevant member
 database(s), allowing users to see at a glance whether a particular
 family or domain has associated patterns, profiles, fingerprints, etc.
 Merged and individual entries (i.e., those that have no counterpart
 in the companion resources) are assigned unique accession numbers.
 Each InterPro entry lists all the matches against SWISS-PROT and TrEMBL

 (more than 860,000 hits in total).


 InterPro release 0.1 beta (October 1999) contains 2423 entries,
 representing 615 domains, 1776 families, 27 repeats, and
 8 post-translational modification sites.
 612 entries are flagged as subtype of other InterPro entries.
 Overall, InterPro matches 186255 of 279794 SWISS-PROT + TrEMBL
 protein sequences. A complete list is available from the ftp site.

 The release was build using the following database versions:

                     Database          Version  Entries    Date
                     ---------         -------  -------    ------
                     SWISS-PROT          38      80000   24-JUL-1999
                     TrEMBL              11     199794   03-AUG-1999
                     PROSITE             16.0     1370   01-APR-1999
                     prelim. profiles     -        241   10-FEB-1999
                     Pfam                 4.0     1465   11-MAY-1999
                     PRINTS              23.1     1157   15-AUG-1999


 The first production release 1.0 is scheduled for February 2000.
 In Release 1.0, we will replace the concatenated annotation
 by manually curated annotation, checked for conflicts and redundancies.

 It will also contain a one-line-description of all InterPro entries.
 A list of example proteins indicating diversity within the group
 will be included.


 FTP server:     ftp://ftp.ebi.ac.uk/pub/databases/interpro/
 Web site  :     http://www.ebi.ac.uk/interpro


 R.Apweiler (1), T.K.Attwood (4), A.Bairoch (2), A.Bateman (5),
 E.Birney (5), M.Biswas (1), P.Bucher (3), M.D.R.Croning (1,4),
 W.Fleischmann (1), A.Kanapin (1), Y.Karavidopoulou (1), B.Marx (1),
 N.Mulder (1).

 (1) EMBL Outstation European Bioinformatics Institute,
 Wellcome Trust Genome Campus, Hinxton, Cambridge, UK;
 (2) Swiss Institute for Bioinformatics, Geneva, Switzerland;
 (3) Swiss Institute for Experimental Cancer Research,
 Lausanne, Switzerland;
 (4) School of Biological Sciences, The University of
 Manchester, Manchester, UK;
 (5) The Sanger Centre, Wellcome Trust Genome Campus, Hinxton,
 Cambridge, UK;
 (6) CNRS/INRA, Toulouse, France;

Alexander A. Kanapin, Ph.D.         | European Bioinformatics Institute
+44 (0)1223 49 4610                 | Wellcome Trust Genome Campus,
+44 (0)1223 49 4468 (fax)           | Cambridgeshire CB10 1SD, United

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