InterPro is an Integrated Resource of Protein Domains
and Functional Sites. InterPro rationalises the complementary
efforts of the PROSITE, PRINTS, Pfam and ProDom database projects.
Merged annotations from PRINTS, PROSITE and Pfam form the InterPro
Each combined InterPro entry includes functional descriptions and
literature references, and links are made back to the relevant member
database(s), allowing users to see at a glance whether a particular
family or domain has associated patterns, profiles, fingerprints, etc.
Merged and individual entries (i.e., those that have no counterpart
in the companion resources) are assigned unique accession numbers.
Each InterPro entry lists all the matches against SWISS-PROT and TrEMBL
(more than 860,000 hits in total).
RELEASE 0.1 BETA OF InterPro
InterPro release 0.1 beta (October 1999) contains 2423 entries,
representing 615 domains, 1776 families, 27 repeats, and
8 post-translational modification sites.
612 entries are flagged as subtype of other InterPro entries.
Overall, InterPro matches 186255 of 279794 SWISS-PROT + TrEMBL
protein sequences. A complete list is available from the ftp site.
The release was build using the following database versions:
Database Version Entries Date
--------- ------- ------- ------
SWISS-PROT 38 80000 24-JUL-1999
TrEMBL 11 199794 03-AUG-1999
PROSITE 16.0 1370 01-APR-1999
prelim. profiles - 241 10-FEB-1999
Pfam 4.0 1465 11-MAY-1999
PRINTS 23.1 1157 15-AUG-1999
UPDATES OF InterPro
The first production release 1.0 is scheduled for February 2000.
In Release 1.0, we will replace the concatenated annotation
by manually curated annotation, checked for conflicts and redundancies.
It will also contain a one-line-description of all InterPro entries.
A list of example proteins indicating diversity within the group
will be included.
FTP server: ftp://ftp.ebi.ac.uk/pub/databases/interpro/
Web site : http://www.ebi.ac.uk/interpro
InterPro HAS BEEN PREPARED BY:
R.Apweiler (1), T.K.Attwood (4), A.Bairoch (2), A.Bateman (5),
E.Birney (5), M.Biswas (1), P.Bucher (3), M.D.R.Croning (1,4),
W.Fleischmann (1), A.Kanapin (1), Y.Karavidopoulou (1), B.Marx (1),
(1) EMBL Outstation European Bioinformatics Institute,
Wellcome Trust Genome Campus, Hinxton, Cambridge, UK;
(2) Swiss Institute for Bioinformatics, Geneva, Switzerland;
(3) Swiss Institute for Experimental Cancer Research,
(4) School of Biological Sciences, The University of
Manchester, Manchester, UK;
(5) The Sanger Centre, Wellcome Trust Genome Campus, Hinxton,
(6) CNRS/INRA, Toulouse, France;
Alexander A. Kanapin, Ph.D. | European Bioinformatics Institute
+44 (0)1223 49 4610 | Wellcome Trust Genome Campus,
+44 (0)1223 49 4468 (fax) | Cambridgeshire CB10 1SD, United