CALL FOR PROPOSALS
CLINICAL TRIALS & BIOASSAYS OF IMMUNE TOLERANCE
The Immune Tolerance Network is seeking applications for clinical trials
and biomarker studies to measure tolerance induction in a range of
targeted diseases, including: islet transplantation; kidney
transplantation; autoimmune disorders such as Type I diabetes, lupus
erythematosus, rheumatoid arthritis, multiple sclerosis and others; and
allergy & asthma.
The Network will accept proposals from all interested parties for Phase
I-II trials of novel therapies that have a strong biological basis for
inducing tolerance and for which pre-clinical investigation is complete,
with encouraging results. Of particular interest are trials combining
immunoregulatory agents which have not yet been tested together.
Proposals will also be accepted for studies aimed at developing or
validating assays of immune tolerance that will complement the clinical
portion of the Network's research portfolio.
The Immune Tolerance Network is a collaborative research program
involving individuals from over 40 institutions world wide that
solicits, develops, implements and assesses clinical strategies and
biological assays for the purposes of inducing, maintaining and
monitoring tolerance in humans. The ITN is jointly sponsored by the
National Institute of Allergy and Infectious Diseases, the National
Institute of Diabetes and Digestive and Kidney Disease and the Juvenile
Diabetes Foundation International.
Applicants are requested to complete a short electronic "Concept
Proposal", a roughly two page summary of the intended research by
December 15, 1999 for the first funding cycle, or February 8, 2000 for
the second. More detailed project information and application forms can
be found on the Network website at www.immunetolerance.org .