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IBC Display Technologies Conference

Andrew Wallace a.wallace at qub.ac.uk
Tue Dec 10 13:03:50 EST 1996

IBC's International Conference on Display Technologies
In Protein Engineering, Drug Discovery, Molecular Evolution and 
Vaccine Development
February 10-11, 1997 * Caesars Tahoe Hotel and Casino * Lake Tahoe, NV

Drug Design
* Small molecule drugs from phage * Vaccine developments * Protease 
inhibitors * High affinity agonists and antagonists * bFGF inhibitors 
* IL-1 receptor antagonists * Kunitz domain inhibitors of serine 
proteases * Structure/function analysis * Disease-specific epitopes

Alternate Display Technologies
* Phage and bacterial library crossing *FLITRX * Novel biological 
diversity systems * Filamentous phage selection * Eukaryotic virus 

New Targets 
* Orphan sites * Genomics * Selection by catalytic activity * In vivo 
systems * BNP analogs 
* Zymogen 

Emerging Approaches
* Phage and bioinformatics * In vivo panning * Protein-protein 
interactions * Rebuilding proteins by size reduction * Screening of 
cDNA expression libraries * Modified receptor interactions * Protein 

IBC gratefully acknowledges Jill Winter of Chiron Corporation for her 
assistance as a scientific advisor for this meeting.

Complimentary book to the first 50 paid, registered delegates!
Phage Display of Peptides and Proteins is an insightful step-by-step 
discussion of phage display protocols for preparing affinity reagents, 
monoclonal antibodies and evolved proteins. Both novices and experts 
will benefit from this book which outlines strategies for maximizing 
the successful application of phage display technology to one's 
research. Editors: Brian K. Kay, University of North Carolina, Jill 
Winter, Chiron Corporation, John McCafferty, Cambridge Antibody 
Technology. Complimentary copies will be given to the first 50 fully 
paid, registered delegates of this meeting. Books may be picked up by 
delegates during conference registration.

IBC USA Conferences, Inc.
225 Turnpike Road
Southborough, MA 01772-1749, U.S.A.
Tel: (508) 481-6400 * Fax: (508) 481-7911
E-mail: reg at ibcusa.com
On-line: http://www.io.org/~ibc/phage

Monday, February 10, 1997
8:00 Registration, Poster/Exhibit Set-Up, Coffee and Breakfast 

Display Technologies in Peptide Optimization
9:00 Chairperson's Welcome and Opening Remarks
Riccardo Cortese, M.D., Ph.D., Scientific and Managing Director, IRBM, 

9:15 Discovering Orphan Sites on Multifunctional Proteins by 
Phage Display
Steve Rosenberg, Ph.D., Senior Director of Biological Chemistry, 
Chiron Corporation

9:45 Defining Peptide Binding Motif for MHC Class I Molecules 
Using Phage Display and Artificial Neural Networks
Michael P. Jackson, Ph.D., Director, RW Johnson Pharmaceutical 
Research Institute

10:15 Poster/Exhibit Viewing and Refreshment Break

11:00 Selection Of Disease-Specific Epitopes Using Serum Samples 
and Phage Displayed Libraries
Riccardo Cortese, M.D., Ph.D.

11:30 A Library of Organic Landscapes on Filamentous Phage
Valery A. Petrenko, Ph.D., Research Professor, University of Missouri

12:00 Luncheon

Display Technologies in Protein Libraries and Protein Optimization
1:15 Chairperson's Remarks
Jane Osbourn, Ph.D., Senior Scientist, Cambridge Antibody Technology, 
United Kingdom

1:30 Functional Analysis and Engineering of Heregulin Using 
Phage Display
Marcus D. Ballinger, Ph.D., Postdoctoral Fellow, Genentech, Inc.

2:00 Exploiting the Diversity of Large Phage Libraries
Jane Osbourn, Ph.D.

2:30 Phage Display and Activation of a Zymogen
Laurent S. Jespers, Ph.D., Senior Scientist, Center for Transgene 
Technology and Gene Therapy, Flanders Interuniversity Institute for 
Biotechnology, Belgium 

3:00 Poster/Exhibit Viewing and Refreshment Break

3:45 Selection of BNP Analogs that Have Modified Natriuretic 
Peptide Receptor Interactions
Lisa J. Garrard, Ph.D., Senior Scientist, Scios, Inc. 

4:15 The Design of Potent and Specific Kunitz Domain Inhibitors 
of Serine Proteases: Utilization of Phage Display and Competitive 
Mark S. Dennis, Senior Research Associate, Genentech, Inc.

4:45 Custom Affinity Ligands from Phage Display for Large-Scale 
Charles Arthur Ley, Ph.D., Director of Research, Dyax Corporation

5:15 Close of Day One

Tuesday, February 11, 1997
7:30 Poster/Exhibit Viewing, Coffee and Breakfast Bakeries 

Alternate Display Technologies
8:15 Chairperson's Remarks
Andreas Pluckthun, Ph.D., Professor of Biochemistry, University of 
Zurich, Switzerland

8:30 Selectively Infective Phage (SIP)
Andreas Pluckthun, Ph.D.

9:00 The FLITRX E. coli Random Peptide Library
Brian C. Tripp, Ph.\D., Postdoctoral Research Fellow, Genetics 
Institute, Inc.

9:30 Combining Bacterial and Phage Display for Potential Gene 
Carl Borrebaeck, D.Sc., Professor, Lund University, Sweden

10:00 Poster/Exhibit Viewing and Refreshment Break

10:45 Eukaryotic Virus Display
Ian Jones, Ph.D., Group Leader, Institute of Virology and 
Environmental Microbiology, UK

>From Libraries to Drugs
11:15 Chairperson's Remarks
Brian K. Kay, Ph.D., Associate Professor, University of North Carolina

11:30 Use of Recombinant Peptide Libraries to Identify High 
Affinity IL-1R Type I Antagonists
Stephen Yanofsky, Ph.D., Senior Scientist, Molecular Pharmacology, 
Affymax Research Institute

12:00 Use of Phage Libraries of Long Peptides in Drug Discovery
Wlodek Mandecki, Ph.D., Director, Molecular Immunology, DGI 

12:30 Lunch on your own

1:45 Peptide Inhibitors of Basic FGF
David Israel, Ph.D., Director of Cell Biology, Pharmaceutical 
Peptides, Inc.

2:15 Cloning Novel Genes with Phage-Displayed Peptide Ligands 
Brian K. Kay, Ph.D.

2:45 Searching for Magic Bullets from Peptide Libraries
Erkki Ruoslahti, M.D., President and CEO, The Burnham Institute

3:15 Poster/Exhibit Viewing and Refreshment Break

3:45 The Use of Peptides as Informants in the Design of Novel 
Vaccines and Drugs
Peter Laing, Ph.D., Director of Research, Peptide Therapeutics, United 

4:15 Small Molecule Drugs from Phage Display Selected Proteins
Robert Charles Ladner, Ph.D., Chief Scientific Officer and Senior Vice 
President, Dyax Corp.

4:45 Human cDNA Phage Display: A New System for Discovering Drug 
Allan Peng, Ph.D., President, GeneMax, Inc.

5:15 Close of Conference

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