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CALL FOR VOTES: P450/bionet.molecules.p450

BIOSCI Administrator biosci-help at net.bio.net
Fri Dec 6 08:55:39 EST 1996

Voting is now open on the following proposal to create the mailing
list & newsgroup


The charter was not modified as a result of the discussion.

*** NOTE *** We are often running several votes for other newsgroups,
so please be certain to follow the voting directions *carefully*!  If
you just send in a message saying "YES" or "NO" it will not be counted
if it is not clear which proposal you are responding to.

Proposal for P450/bionet.molecules.p450

USENET newsgroup name:  bionet.molecules.p450

Status:			Unmoderated

One line Description:   Research on cytochrome P450

Mailing list name:      P450

E-mail addresses:       p450 at net.bio.net
                        p450 at daresbury.ac.uk

Discussion leader:      Dr. A. Zimmerlin
                        Alfred.zimmerlin at fmi.ch
Newsgroup Charter:

bionet.molecules.p450 is a forum for scientific discussions and a
source of information for the community of biologists interested in any
aspect of cytochrome P450 research.

Functions of the newsgroup:

The newsgroup will facilitate rapid communication among research
scientists, educators and industries investigating cytochrome P450
function, structure, mechanism, biochemistry and molecular biology.

Formation of this newsgroup will provide :

- a forum for the discussion of ideas, problems, and recent
developments in the study of P450;

- a means of obtaining practical advice and answers to frequently
asked questions;

- a means of obtaining research protocols, strains, unique reagents
(e.g.inhibitors, substrates, antibodies, cDNA clones, primers and gene
sequences, DNA libraries, mutants, etc.);

- a means of developing collaborations between laboratories;

- a bulletin board for any announcements concerning meetings,
congresses, new informational databases, job offers, funding sources
of interest, etc., related to P450 research.

Discussion topics will include (among other more specific topics):

- substrates and inhibitors,
- marker activities,
- xenobiotic metabolism,
- physiological role,
- biosynthetic forms,
- extrahepatic forms,
- purification,
- antibodies and cross-reactivity
- isozyme profiling,
- drug interactions,
- reconstitution of activity,
- types of reactions,
- catalytic mechanism,
- regulation (hormone, age, gender, senescence, xenobiotics,...),
- crystallization and three-dimensional models,
- active site topology,
- model systems,
- cloning strategies,
- evolution and nomenclature,
- phylum specific P450s,
- genetic polymorphisms,
- protein-protein  and lipid-protein interactions,
- posttranslational modification,
- heterologous expression.
- computer assisted "sequence-structure-function" relationships,
- prediction of drugs side and toxic effects,
- P450 resourses in the Internet.

Discussions on regulation and function of related enzyme systems such as
peroxidases, FMO's, GST's, UDPGT's, NAT's, etc., are welcome.

This news group will not be moderated (edited). Participants shall
adhere to the general regulations regarding posting to news groups: a)
individuals posting information to this forum should use proper
"netiquette", b) the forum is not intended to aid students with their
homework assignments, c) the forum is used only for non-commercial
purposes, d) individuals must avoid conflicts of interest when posting

Subscribers are welcome from universities or any academic institutions,
government agencies, medical institutions, and industrial or commercial
organizations. Contributions within the functions outlined above are

Dr. Alfred Zimmerlin
Ciba-Geigy AG
Drug Metabolism and Exploratory Toxicology
CH-4002 Basel
Tel: (41) 616963101
Fax: (41) 616966212

Voting is now open on the proposal for
P450/bionet.molecules.p450 and will run through 24:00 hrs
Pacific Time on 4 January 1996.  Please send your vote to either of
the following addresses:

Address                               Location        Network
-------                               --------        -------
biovote at daresbury.ac.uk               U.K.            JANET
biovote at net.bio.net                   U.S.A.          Internet/BITNET

NAME MAY BE AMBIGUOUS.  Your vote should contain a single line:

YES on P450

if you favor allowing the creation of this newsgroup or

NO on P450

if you think that this proposal will adversely affect the
BIOSCI/bionet system.  While not intended to be an exhaustive list of
possible concerns (more specific concerns may have been raised during
the discussion period on BIOFORUM/bionet.general and interested
readers are referred to these), some general reasons for voting NO
might be if you are concerned about newsgroup proliferation and/or
believe that the proposed group will not be utilized, or if you think
that the proposed newsgroup would substantially duplicate or overlap
with the function of existing newsgroups.  If you are simply not
interested in participating in the newsgroup above, please don't cast
a NO vote, but instead just don't vote at all.

The newsgroup proposal must receive at least 80 YES votes to pass and
the number of YES votes must be greater than the number of NO votes by
at least 40.  Discussion of the newsgroup proposal is now closed and
we strongly discourage posting any messages in other forums about the
fact that a CALL FOR VOTES has been issued.


				Dave Kristofferson
				BIOSCI/bionet Manager

				biosci-help at net.bio.net

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