Mammalian Homology and Enzyme Function Data now available from GDB!
The Genome Data Base (GDB) has re-established links from over 1500 GDB human
gene entries to the mammalian homology data within the Mouse
Genome Database (MGD). While the primary focus of MGD is mouse, their
homology data includes information on mammals from the baboon to the
wallaby! These data include gene symbols, cytogenetic locations and
citations. To access the GDB/MGD homology links, follow the steps
outlined below to perform a gene search in GDB, then follow the "Homology"
link to MGD.
Links to enzyme function data for over 400 protein products
of human genes can also be found in GDB. Enzyme data is based on Enzyme
Commission (EC) numbers as maintained by the Enzyme nomenclature database
at SWISS-PROT. The Enzyme database entries include the reaction catalyzed,
cofactor(s), links to the PROSITE database (protein sites and patterns),
and detailed SWISS-PROT entries that include protein sequence and links to
many other databases.
To access mammalian homology and enzyme function data
from GDB, start at the GDB homepage (http://gdbwww.gdb.org).
Select the "Quick Search" option.
Enter the symbol for your favorite gene as the "Genome Object Name", e.g.
SOD1, and press "Submit".
Choose "Gene SOD1" from the list of query results returned.
For mammalian homology data:
Choose "Mouse Genome Database: Sod1" from the "Homologies" section of the
information returned for the SOD1 gene.
For enzyme function data:
Choose "Protein: Superoxide Dismutase" from the
information returned for the SOD1 gene. (The enzyme function links have
been made from the genes via their protein products).
The link to the EC database is visible under "Enzyme Links": EC 18.104.22.168
Amy K. Voltz
avoltz at gdb.org