[Bioforum] Re: The problem of disseminated tumor cells in breast cancer.

[scimedweb At mail.com]

Significance, detection and markers of disseminated breast cancer
cells.
by Marc Lacroix
InTextoResearch, Baelen, Wallonia, Belgium & Jules Bordet Institute,
Brussels, Belgium
Now in Endocrine-Related Cancer 13 (4) 1033-1067 (December 2006)

http://erc.endocrinology-journals.org/cgi/content/full/13/4/1033




scimedweb At mail.com a écrit :

> Significance, detection and markers of disseminated breast cancer
> cells.
> by Marc Lacroix
> InTextoResearch, Baelen, Wallonia, Belgium & Jules Bordet Institute,
> Brussels, Belgium
> in Endocrine-Related Cancer (in press)
>
> http://www.geocities.com/m.lacroix/erc3.htm
> http://journals.endocrinology.org/erc/fca/ERC00001.htm
>
>
> The development of distant metastases is the major cause of death from
> breast cancer. In order to predict and prevent tumour spreading, many
> attempts are being made to detect small numbers of tumour cells that
> have shed from the primary lesions and have moved to lymph nodes, blood
> or bone marrow. A review presents the advantages and limitations of
> techniques used for disseminated tumour cells (DTC) detection in breast
> cancer. DTC markers are listed and the most currently used of them
> (KRT19/CK19, CEACAM5/CEA, TACSTD1/GA733-2/TROP1, MUC1, EGFR, ERBB2,
> SCGB2A2/MAMMAGLOBIN, SCGB2A1/MAMMAGLOBIN2, SCGB1D2, PIP/GCDFP15, SBEM,
> TFF1/pS2, TFF3, ANKRD30A/NY-BR-1, SPDEF/PDEF, ESR1, SERPINB5/MASPIN,
> and GABRP) are discussed, notably on the basis of recent data on breast
> tumour portraits ("luminal epithelial-like",
> "basal/myoepithelial-like" and "ERBB2/Her2/neu"). The
> significance of DTC for prognosis and prediction of response to therapy
> is examined. DTC viability, the notion of cell dormancy and the concept
> of breast cancer stem cells are also discussed.