If a drug induces apoptotic cell death, you should be able to see the
hallmarks of apoptosis, e. g. depolarisation of mitochondrial membrane,
exposure of phosphatidylserine on the outer membrane leaflet, cleavage of
effector caspases and caspase substrates, DNA fragmentation, etc. Go for
these.
Cornelius
"Bob" <xyzbbruner at uclink4.berkeley.edu> schrieb im Newsbeitrag
news:4m5dtvg545tcj5tueev3pl6rpd5nfjc70n at 4ax.com...
> On 9 Dec 2003 23:17:55 -0000, zy2012 at columbia.edu wrote:
>> >
> >Hi Everyone
> >I have the following question for long time. I hope I can get
> >answer from you. Thank you in advance.
> >Any drug can cause apoptosis as long as the concentration of the
> >drug is enough high to injure the cell.
>> ?? I'm not sure that is true. Apoptosis is not merely death, but a
> specific style of death.
>>> >However, some drugs can
> >truly induce apoptosis. This is a traditional concept of apoptosis.
> >So, how do we identify a drug which can induce traditional
> >apoptosis.
>> I think we need to resolve the first point before addressing this one.
>> bob
>>
