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[Arabidopsis] Grant-funded PhD student position in herbicides and protein biochemistry - Perth, Australia

Josh Mylne via arab-gen%40net.bio.net (by joshua.mylne from uwa.edu.au)
Fri Jan 11 15:42:30 EST 2019


A PhD student position is available to work on herbicide target discovery i=
n sunny Perth, Western Australia. The position is with Associate Professor =
Josh Mylne, based within the School of Molecular Sciences, which runs the m=
ajors of genetics, biochemistry and chemistry at The University of Western =
Australia (www.uwa.edu.au) in Perth, Australia. This is a 3-year position a=
nd carries a tax-free stipend of AUD 30,000 p.a. Associate Professor Mylne =
is a former Australian Research Council QEII and Future Fellow (2008-2016),=
 the 2012 Goldacre medalist, a 2018 Fulbright Professional Scholar and labo=
ratory head (www.mylne.org) since 2013. His lab is organising the Herbicide=
 Discovery & Development meeting in Perth in 2020 (http://hdd2020.org).

The PhD project pursues new herbicide targets, both their discovery and cha=
racterization. The success of glyphosate and spiraling cost of bringing new=
 compounds has meant no new herbicide mode of action has reach the market i=
n several decades. Herbicide resistance also has growers concerned. Using a=
ntimalarial drug libraries, knowledge of malarial drug action and by lookin=
g more broadly, the team working in this area are attempting to put as many=
 new modes of action =91on the table=92 as possible.

The PhD project will involve recombinant protein production, enzymology, bi=
ochemical assays, and protein crystallography. There is also scope to acqui=
re skills in classical forward genetics and reverse genetics in Arabidopsis=
 thaliana.

References relevant to the project and see http://mylne.org/herbicides.html

- Corral, Haywood, Stehl, Stubbs, Murcha, Mylne* (2018) Targeting plant DIH=
YDROFOLATE REDUCTASE with antifolates and mechanisms for genetic resistance=
. Plant Journal (PMID 29876984
- Wallace, Waraich, Debowski, Corral, Maxwell, Mylne*, Stubbs* (2018) Devel=
oping ciprofloxacin analogues against plant DNA gyrase: a novel herbicide m=
ode of action. Chem Commun. (PMID 29388638)
- Corral, Leroux, Tresch, Newton, Stubbs*, Mylne* (2018) A herbicide struct=
ure-activity analysis of the antimalarial lead compound MMV007978 against A=
rabidopsis thaliana. Pest Manag Sci. (PMID 29377434)
- Corral, Leroux, Tresch, Newton, Stubbs*, Mylne* (2017) Exploiting the evo=
lutionary relationship between malarial parasites and plants to develop new=
 herbicides. Angew. Chem. Int. Ed. Engl. (PMID 28654179)
- Corral, Leroux, Stubbs, Mylne* (2017) Herbicidal properties of antimalari=
al drugs. Scientific Reports (PMID 28361906).
- Gandy, Corral, Mylne*, Stubbs* (2015) An interactive database to explore =
herbicide physicochemical properties. Org. Biomol. Chem. (PMID 25895669)

Applicants should eligible for a PhD in Australia (any queries to joshua.my=
lne from uwa.edu.au) and have a degree in Biochemistry. Molecular Biology or a r=
elated discipline, with excellent communication skills. Experience in prote=
in biochemistry or plant chemical biology is a plus.

Interested candidates should send, before 18 February 2019, their CV and a =
letter of motivation including a brief description of previous activities t=
o joshua.mylne from uwa.edu.au. Short listed candidates will be asked to provide=
 2-3 letters of reference. Please do not send publications or letters of re=
ference or copies of degrees etc unless asked for.

The Mylne lab is based in the Bayliss Building which is a hub of molecular =
research housing the School of Molecular Sciences as well as the ARC Centre=
 of Excellence in Plant Energy Biology. The School of Molecular Sciences is=
 a large, research intensive school with 100 staff, 100 PhD students, and m=
ore than 600 undergraduate students. The School is committed to achieving i=
nternational excellence in teaching, research and service, with activity sp=
anning Chemistry, Biochemistry, Molecular Biology and Molecular Genetics. T=
he building boasts outstanding plant growth facilities as well as establish=
ed, high-throughput, crystal-condition screening platforms and home-source =
X-ray beam-line. Overall this makes it the ideal research environment for p=
lant biological chemistry

The University of Western Australia (UWA) is ranked amongst the top 100 uni=
versities in the world and a member of the prestigious Australian Group of =
Eight research-intensive. For details see http://www.web.uwa.edu.au/univers=
ity/highlights/reputation

Perth is a stunning part of the world to live in; the population is 2 milli=
on and it=92s located on the Swan River where it meets the western coastlin=
e. Perth has pristine beaches with crystal clear water and a Mediterranean =
climate of warm hot summers, and mild winters. On a bike ride to work along=
 the river (most of Perth is flat) you are likely to spot dolphins, pelican=
s and black swans. Perth has the benefits of cosmopolitan big city living, =
but without the overcrowding. We like to think Australia is =91the lucky co=
untry=92, but we=92re not the only ones to think so, see this special issue=
 on Australia from the Economist published October 2018 at http://goo.gl/re=
wBbs

Remember to submit CV and a letter of motivation to joshua.mylne from uwa.edu.au=
 by 18 February 2019.


Josh

----
Fulbright Professional Scholar
Department of Biochemistry, Molecular Biology & Biophysics
The University of Minnesota

M: +1 651 206 6653
E: joshua.mylne from uwa.edu.au
W: www.mylne.org



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