Arabidopsis Molecular Geneticist
Fellow Position at Rutgers, the State University of New Jersey
Subject area: Plant Cell Death Regulation.
NSF funded postdoctoral fellow position is available immediately to work on the
mechanisms of programmed cell death control in Arabidopsis thaliana by a family of conserved cysteine proteases
called metacaspase. Recent genetic and
biochemical studies have demonstrated the involvement of some members of this
protease family in regulating plant cell death activation by oxidative
stresses, and the importance of posttranslational mechanisms for regulating
their activity in vitro and in planta. Molecular, genetic and biochemical approaches
will now be deployed to further dissect the structural basis of these
regulatory functions. In particular, a
novel RNA-display technology developed in our collaborator Dr. Rihe Liu's
laboratory at UNC Chapel Hill (North Carolina) will be used to delineate the Arabidopsis
degradome candidates downstream from metacaspases. Applicants should have a recent PhD in
molecular genetics, preferably with experience in Arabidopsis. Ability to carry out experimental work
independently is essential and an interactive personality highly
desirable. Interested applicants should
send a CV, brief summary of research experience, and names and email addresses
of 3 referees to Dr. Eric Lam
(Lam from aesop.rutgers.edu).
Applications will be reviewed until the position is filled.
Rutgers University is an equal opportunity/affirmative
Recent papers on metacaspases from the Lam lab:
the Reapers Activating metacaspases for programmed cell death (2013) Eric
Lam and Yi Zhang, Trends in Plant
Science 17, 487-494.
the swords of death: Post-translational modulation of plant metacaspases
(2011) Yi Zhang and Eric Lam, Plant Signal Behav. 6, 2051-2056.
activation and autolysis of Arabidopsis metacaspase 2d (2011) Naohide Watanabe
and Eric Lam, J. Biol. Chem.
Metacaspase 2d is a positive mediator of cell death induced during biotic and abiotic
stresses (2011) Naohide Watanabe and Eric Lam , The Plant Journal 66, 969-982.
Recent papers on RNA-Display
from the Liu lab:
"In vitro selection of proteins with desired
characteristics using mRNA-display" (2013) Valencia CA, Zou J, Liu R. Methods 60(1): 55-69
of proteins with desired properties from natural proteome libraries using mRNA
display" (2011) Cotten SW, Zou J, Valencia CA, Liu R. Nat Protoc. 6(8): 1163-82.
selections for proteins with desired functions: a protease-substrate case study" (2008) Valencia CA, Cotten SW, Dong B, Liu R. Biotechnol Prog. 24(3): 561-9.
Plant Biology & Pathology
Rutgers, the State University of New Jersey
Foran Hall, Rm. 216
59 Dudley Road
New Brunswick, NJ 08901
Ph: 848-932-6351 (office)
Ph: 848-932-6273 (lab)
email: Lam from aesop.rutgers.eduhttp://aesop.rutgers.edu/~lamlab/