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[Arabidopsis] Post-doctoral position at Brown University

Alison DeLong Alison_DeLong at brown.edu
Fri Jan 6 18:13:54 EST 2006



POSTDOCTORAL RESEARCH POSITION
REGULATION OF PROTEIN PHOSPHATASE 2A ACTIVITY

Laboratory of Alison DeLong
Brown University, Providence Rhode Island
http://www.brown.edu/Divisions/Medical_School/andera/profile.php?id=1100923978

A postdoctoral position is available for a period 
of up to three years to study the regulation of 
Arabidopsis protein phosphatase 2A (PP2A) by its 
scaffolding/regulatory A subunits.  PP2A is an 
abundant heterotrimeric serine/threonine protein 
phosphatase with broad substrate specificity and 
a diverse repertoire of cellular functions.  The 
RCN1 gene and its paralogs PP2AA2 and PP2AA3 
encode the three regulatory A subunits, and loss 
of RCN1 function leads to reduced PP2A activity, 
alterations in polar auxin transport and 
pleiotropic effects on plant growth.  Mutations 
in PP2AA2 and PP2AA3 have little effect on 
overall PP2A activity, but functions of the 
isoforms encoded by these genes are unmasked in 
the rcn1 mutant background.  Currently we are 
defining the molecular basis for functional 
specialization of A subunit isoforms, 
characterizing the composition of PP2A complexes 
in mutant and wild-type plants, and taking a 
phosphoproteomic approach to identification of 
PP2A substrates.

Candidates must have a strong background in 
molecular genetics and/or biochemistry.  To 
apply, please send your current CV, a letter 
outlining your research interests and 
accomplishments, and arrange to have three 
letters of reference sent directly to Prof. 
Alison DeLong; Dept. of Molecular Biology, Cell 
Biology and Biochemistry; Brown University; 
Providence RI  02912; TEL 401-863-3888; FAX 
401-863-2421.  Alison_DeLong at brown.edu

For additional information see:
Zhou, H.W., C. Nussbaumer, Y. Chao and A DeLong 
(2004) Disparate roles for the regulatory A 
subunit isoforms in Arabidopsis protein 
phosphatase 2A.  The Plant Cell 16:709-722.

Rashotte, A. M., A. DeLong and G. K. Muday (2001) 
Genetic and chemical reductions in protein 
phosphatase activity alter auxin transport, 
gravity response and lateral root growth. The 
Plant Cell 13: 1683-1697.

Deruère, J., K. Jackson, C. Garbers, D. Söll and 
A. DeLong (1999)  The RCN1-encoded A subunit of 
protein phosphatase 2A increases phosphatase 
activity in vivo. The Plant Journal 20: 389-399.

Lizotte, D., D. D. McManus, H. R. Cohen, and A. 
DeLong (1999)  Functional expression of human and 
Arabidopsis protein phosphatase 2A in 
Saccharomyces cerevisiae and isolation of 
dominant-defective mutants. Gene 234: 35-44.


--
Alison DeLong, Ph.D.
Assistant Professor
Dept of Molecular Biology, Cell Biology and Biochemistry
Brown University
Providence RI  02912
TEL 401-863-3888
FAX  401-863-2421


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