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Postdoctoral and PhD student positions

Toshiro Ito itot at its.caltech.edu
Thu Mar 10 13:01:50 EST 2005

<x-flowed>Two postdoctoral and two PhD student positions are available in the
Plant Systems Biology laboratory of Toshiro Ito at the Temasek Life
Sciences Laboratory (http://www.tll.org.sg/) of National University
of Singapore starting on October 1, 2005.

It is a longstanding mystery and very intriguing question how
homeotic proteins specify organ identity during both animal and plant
development. The homeotic gene AGAMOUS (AG), a MADS-box transcription
factor, is necessary for the specification of reproductive organs in
the model plant Arabidopsis. We aim to elucidate the transcriptional
network structure from AG to downstream genes that control the
morphogenesis of reproductive organs by the high-throughput analyses
of microarray and chromatin immunoprecipitation (ChIP) focusing on
the following four facets:

1. Gametophyte induction
We recently showed that AG regulates SPOROCYTELESS (NOZZLE, SPL) as a
central mediator for microsporogenesis function (Nature 430,
356-360). One project is to reveal downstream cascades of SPL
controlling the transition from the sporophytic to the gametophytic

2. Late stage function
In addition to playing a role in microsporogenesis, AG appears to
have several different functions for the maturation of reproductive
organs. The second project is to reveal the downstream targets of AG
during the late stages of flower development.

3. Meristem determinacy
The third project involves another important function of AG:
terminating meristematic activity by repressing the WUSCHEL (WUS)
expression in floral buds. We plan to reveal how AG controls WUS and
fill a gap in the transcriptional cascades from AG to WUS.

4. Functional analysis of a nuclear protein
The fourth project is the functional characterization of one of our
putative AG targets. This gene encodes a nuclear protein that may
function by interacting with the nuclear matrix and recruiting
chromatin remodeling enzymes. This project potentially reveals a
mechanism for orchestrated transcriptional regulation of multiple
genes during reproductive organ development. It involves
reverse-genetics and biochemical analyses.

Temasek Life Sciences Laboratory (TLL) is a non-profit organization
established to undertake cutting edge research in cell biology,
developmental biology, neuroscience, pathogenesis and bioinformatics.
TLL focuses primarily on understanding the cellular mechanisms that
regulate the development and physiology of yeast, plants, and
animals. TLL is affiliated to the National University of Singapore
and Nanyang Technological University. It is located within the
sprawling campus of the National University of Singapore and is
situated alongside other research institutes and academic departments
of the university.

   In TLL, our research group will have close interactions with two
established laboratories working on Arabidopsis flowering (Dr. Yu
Hao) and epigenetics (Dr. Frederic Berger).
Salary and benefits are competitive.
Review of applicants will start immediately and continue until
candidates are identified.
Postdoc applicants are expected to have a strong background in
genetics and molecular biology. Above all, people with determination
and enthusiasm for science are encouraged to apply.
The candidates for Ph.D fellowships can follow the instruction in the
webpage (http://www.tll.org.sg/career/phd.asp) to submit their
Interested postdoc candidates should send a curriculum vitae and
contact information for three references to:

Toshiro Ito
   itot at its.caltech.edu
California Institute of Technology
Division of Biology 156-29
1200 E. California Blvd. Pasadena CA 91125, USA
telephone: 1-626-395-4936  fax: 1-626-449-0756


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