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postdoc position

Nobody nobody at hgmp.mrc.ac.uk
Thu Jul 31 10:37:35 EST 2003

Postdoctoral Position

A 2 years postdoctoral position is open at INRA, Versailles, France, 
in the "Meiosis and Recombination" laboratory. The main focus of our 
group is centred on deciphering the mechanisms of mitotic and meiotic 
recombination in the model plants Arabidopsis thaliana and 
Physcomitrella patens.  The postdoctoral project aims to improve 
understanding of the control of the formation and the position of DNA 
double-stranded breaks created by the meiotic AtSPO11-1 protein which 
initiates meiotic recombination. Two complementary approaches will be 
pursued. The first one will concentrate on the targeting of meiotic 
double strand breaks in Arabidopsis thaliana using a fusion between 
AtSPO11-1 and the DNA binding domain of the Gal4 protein. This 
strategy has been successful in S. cerevisiae (Pecina, Smith, Mezard 
et al, Cell, 2002, 11, 173-184). With the second approach, we will 
try to identify the partners of the AtSPO11-1 protein. A mutant 
Arabidopsis family containing a T-DNA insertion in one of the 
potential partners of AtSPO11-1 will be analysed.
The successful candidate will join an important institute of 
geneticists and molecular biologists working on plant reproduction 
and will benefit from the various tools and materials available and 
developed in the institute: insertional mutants of the Versailles 
collection of T-DNA transformants, FSTs of this collection, strong 
cytology, molecular biology and genetics expertise (Mercier et al., 
Development, 2003, 130, 3309-18; Grelon et al., EMBO, 2001, 20, 
589-600). A background in molecular biology and genetics will be 
Applicants should not be French. Salary range : 1530-2100 =A4/month, 
depending on experience.
Please forward an application outlining research experience and 
interests, curriculum vitae and addresses of two referees to 
Christine M=E9zard, INRA, Station de G=E9n=E9tique et d'Am=E9lioration des 
Plantes, route de Saint Cyr, 78026 Versailles cedex, France, 
Christine.Mezard at versailles.inra.fr, tel: (33) 1 30 83 35 23, fax 
(33) 1 30 83 33 19.

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