A postdoctoral researcher position is available immediately to study
the regulatory functions of sterols in plant embryogenesis. Plant
steroid hormones play important roles in regulating a variety of
cellular activities and development. In the past, only
brassinosteroids (BRs) have been demonstrated to have hormonal
effects in post-embryonic growth. Other sterols have been considered
simply as membrane structural components. However, several recent
studies have suggested that besides BRs, other sterols are also
critically involved in the regulation of both embryonic and
post-embryonic development. While this is primarily established
through genetic studies, the underlying molecular and cellular
mechanisms are not known. Our goal is to determine the signaling
role of non-BR sterols in cell division, cell expansion, and
embryogenesis in plants. We will be using both the whole plant and a
cellular system to dissect a putative sterol signaling pathway in
Arabidopsis. Applicants with a Ph.D. and a strong background in cell
biology and molecular genetics should send a statement of interest,
curriculum vitae, and contact information for three references to: J.
C. Jang, Dept. of Horticulture and Crop Science, Ohio State
University, E-mail: jang.40 at osu.edu
Carland, F.M., Fujioka, S., Takatsuto, S., Yoshida, S., and Nelson,
T. (2002). The Identification of CVP1 Reveals a Role for Sterols in
Vascular Patterning. Plant Cell 14, 2045-2058.
Clouse, S.D. (2000). Plant development: A role for sterols in
embryogenesis. Curr. Biol. 10, R601-R604.
Clouse, S.D. (2002). Arabidopsis mutants reveal multiple roles for
sterols in plant development. Plant Cell 14, 1995-2000.
Diener, A.C., Li, H., Whoriskey, W.J., Nes, D., and Fink, G.R.
(2000). STEROL METHYLTRANSFERASE 1 controls the levels of cholesterol
in plants. Plant Cell 12, 853-870.
Jang, J.-C., Fujioka, S., Tasaka, M., Seto, H., Takatsuto, S., Ishii,
A., Aida, M., Yoshida, S., and Sheen, J. (2000). A critical role of
sterols in embryonic patterning and meristem programming revealed by
the fackel mutants of Arabidopsis thaliana. Genes Dev. 14, 1485-1497.
Schaeffer, A., Bronner, R., Benveniste, P., and Schaller, H. (2001).
The ratio of campesterol to sitosterol that modulates growth in
Arabidopsis is controlled by STEROL METHYLTRANSFERASE 2;1. Plant J
Schrick, K., Mayer, U., Martin, G., Bellini, C., Kuhnt, C., Schmidt,
J., and Jurgens, G. (2002). Interactions between sterol biosynthesis
genes in embryonic development of Arabidopsis. Plant J 31, 61-73.
Schrick, K., Mayer, U., Horrichs, A., Kuhnt, C., Bellini, C., Dangl,
J., Schmidt, J., and Jurgens, G. (2000). FACKEL is a sterol C-14
reductase required for organized cell division and expansion in
Arabidopsis embryogenesis. Genes Dev. 14, 1471-1484.
Souter, M., Topping, J., Pullen, M., Friml, J., Palme, K., Hackett,
R., Grierson, D., and Lindsey, K. (2002). hydra mutants of
Arabidopsis are defective in sterol profiles and auxin and ethylene
signaling. Plant Cell 14, 1-15.
Dept. of Horticulture and Crop Science
Dept. of Plant Biology
Ohio State University
Phone: (614) 292-8496 (office)
(614) 292-9116 (lab)
Fax: (614) 292-7162
email: jang.40 at osu.edu
Graduate Studies in Plant Molecular Biology and Biotechnology Program (PMBB)