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PhD position in plant cell / secondary metabolism / membrane biolog=

Nobody nobody at hgmp.mrc.ac.uk
Thu Oct 17 06:10:26 EST 2002

<x-charset iso-8859-1>PhD position announcement

A PhD is open immediately for application in the laboratory of Markus
Klein (Molecular Plant Physiology, Head Enrico Martinoia, Plant Biology,
University of Zurich).

In this project which is supported by the Forschungskommission und
Nachwuchsf=96rderungskommission der Universit=94t Z=B8rich different transpo=
routes for secondary compounds will be investigated on a cellular and
molecular level. Secondary compounds which fulfill prime functions to
increase the ecological fitness of plants often are accumulated at high
concentrations in the vacuole or the extracellular space. In the past we
characterized a range of vacuolar transport mechanisms for phenolic
compounds (Klein et al., (1996) JBC, 271, 29666; Klein et al. (1998)
JBC, 273, 262; Klein et al., (2000) Plant J., 21, 289; Frangne et al.
(2002) Plant Physiol., 128, 726) and are on the way to identify
corresponding transporters on the molecular level (e.g. Gaedeke et al.
(2001), EMBO J., 20, 1875). It has been stated in some cases that
secondary compounds may reach the vacuole or the apoplast by
vesicle-mediated transport. Using a range of state-of-the-art molecular
and microscopical tools including analytical systems for these compounds
and model systems with fluorescent secondary compounds we will try to
characterize vesicle-mediated transport of phenolic compounds, identify
components which are involved in this phenomenon and investigate a novel
cytotic route from the vacuole to the apoplast.

The institute is located in the nice Botanical Garden in the wonderful
city of Zurich.

Candidates should send their C.V. and 1-3 addresses of potential
referees to Markus Klein (markus.klein at botinst.unizh.ch), Universit=94t
Z=B8rich, Institut f=B8r Pflanzenbiologie, Zollikerstrasse 107, CH-8008
Zurich, Switzerland or call +41-1=F3634.82.82.

Hope to hear from you soon,
Dr. Markus Klein
University of Zurich
Plant Biology - Molecular Plant Physiology
Zollikerstrasse 107
CH-8008 Zurich
e-mail: markus.klein at botinst.unizh.ch
www: http://www.unizh.ch/botinst/
Tel.: +41'1'634'8282



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