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Post Doc Position at John Innes Centre, Norwich, UK

Dee Rawsthorne dee.rawsthorne at bbsrc.ac.uk
Wed Mar 7 07:02:09 EST 2001

Plant Molecular Biologist/Biochemist

We have a 33 month post for a postdoctoral scientist to study
cytoskeletal genes during the differentiation of Zinnia mesophyll cells
into xylem elements in vitro.

Background: We have biochemically isolated a family of 65kDa
microtubule-associated proteins (MAPs) that form filamentous sidearms
which maintain the parallel spacing of microtubules. In vitro, these
MAPs induce microtubules to form bundles. Dr Maureen McCanns Cell Wall
group  has developed a highly synchronized system in which the initially
evenly distributed cortical microtubules in Zinnia mesophyll cells
bunch-up into hoop-like patterns as they trans-differentiate into
suspensions of xylem cells.  We propose to study the role of the 65kDa
MAPs in this natural microtubule bundling system.

The  project will be to identify the Zinnia MAP65 homologues and
determine whether the pattern of expression of the different isoforms
changes at the time that the microtubules bunch-up. Depending on
progress other cytoskeletal proteins identified by AFLP mapping in the
McCann lab could be studied.

We seek candidates with experience in  plant molecular biology. Ideally
this will have been gained at the postdoctoral level although strong
candidates with a recent PhD in a relevant topic will be considered.

Salary on appointment will be within the range #19,500 to #23,000 per
annum depending on qualifications and experience. Staff have the
opportunity to join a non-contributory superannuation scheme.

The John Innes Centre is a world-ranking centre of excellence in the
plant and microbial sciences and has superb state-of-the-art research
facilities. It has about 650 scientists in 80 groups. Scientists enjoy
good sports and social facilities on a pleasant campus at the edge of
the historic city  of Norwich.

For further details telephone Clive Lloyd on (01603) 450288 or e-mail
clive.lloyd at bbsrc.ac.uk

Further reading
For isolation of MAP 65 see Chan et al, Proc Natn Acad Sci USA 96,
14931. 1999.
For a review of plant MAPs see Lloyd and Hussey, Nature Reviews, Mol
Cell Biol 2, 40. 2001.
For cloning of first plant structural MAP see Smertenko et al Nature
Cell Biol 2: 750. 2000.

Dee Rawsthorne
John Innes Centre
Norwich Research Park
Norwich NR4 7UH

E-mail dee.rawsthorne at bbsrc.ac.uk
Tel: 44 (0)1603 450527
Fax: 44 (0)1603 450025

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