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Postdoctoral Position

Iris Meier meier.56 at osu.edu
Tue Jun 20 19:40:36 EST 2000


A postdoctoral position is available to study the role of the plant nuclear
envelope in chromatin organization and gene expression.

Association of chromatin with the nuclear envelope has been recently
connected with gene silencing and heterochromatin formation in animals and
yeast. So far, no orthologs of the animal inner nuclear envelope proteins
implied in chromatin attachment appear to be present in the Arabidopsis
genome. We have identified two novel, potentially plant-specific proteins
(MFP1 and MAF1) which are located at the nuclear envelope. MFP1 is a
filament-like protein and binds in a phosphorylation-dependent way to
matrix attachment region DNA. It is associated with the nuclear envelope
via a novel targeting domain. MAF1 is a novel protein, which binds in yeast
and in vitro to the coiled-coil domain of MFP1.

Our hypothesis is that MFP1 is involved in attaching chromatin to the plant
nuclear envelope and that MAF1 is involved in this process through
interaction with MFP1. Potential projects for the postdoctoral researcher
are the investigation of changes in nuclear architecture and gene
expression pattern in knock-out mutants of MFP1 and MAF1 in Arabidopsis;
the use of MFP1 and MAF1 as plant nuclear envelope markers during cell
cycle using live dual imaging of GFP fusions; and the cell cycle-dependent
regulation of MAR-binding by phosphorylation.

For further information see: Meier et al. (1996), Plant Cell 8:2105;
Gindullis and Meier (1999), Plant Cell 11:1117; Gindullis et al. (1999),
Plant Cell 11:1755; Harder et al. (2000) Plant Phys. 122:225, and our
webpage.

To apply, please send a CV, a brief statement of research experience and
research interests, and the names of at least three references (including
address, phone, and email) to Iris Meier by mail or email. Successful
postdoctoral candidates will have a Ph.D. and a proven record of
productivity including first-authored publications in internationally
recognized journals. Experience in either fluorescence microscopy or
Arabidopsis molecular genetics will be a plus.

If you are planning to attend the Arabidopsis meeting in Madison, please
send me an email to arrange for a meeting, or meet us at posters 281 and
288.

Iris Meier
Plant Biotechnology Center
Ohio State University
210 Rightmire Hall
1060 Carmack Road
Columbus, OH 43210

PHONE: (614) 292 8323
FAX: (614) 292 5379
email: meier.56 at osu.edu
http://www.biosci.ohio-state.edu/~plantbio/plantbio.html



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