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PhD Studentship available

Roberts, M. mrr5 at york.ac.uk
Thu May 20 10:39:54 EST 1999

BBSRC CASE Studentship available from 1st October 1999
University of york, Department of Biology.

Functional analysis of 14-3-3 protein-protein interactions in plant

14-3-3 proteins function as regulators of many key biological processes
in eukaryotic cells via direct interactions with target proteins [e.g.
see Aitken, A. (1996) Trends Cell Biol. 6; 341-347].  They act in a
variety of ways, either by activating, inhibiting, or altering the
cellular location of their target proteins following binding.  Examples
of proteins regulated by 14-3-3 include structural proteins, metabolic
enzymes, transcription factors and signalling proteins such as
receptors, protein kinases and protein phosphatases.  Interactions with
14-3-3 proteins are often controlled by phosphorylation of 14-3-3
binding sites in the target protein.

This project, which will be carried out jointly with Zeneca
Agrochemicals (Jealotts Hill, Bracknell), will use molecular genetic
approaches to assess the effect of suppressing 14-3-3 function in plant
cells and the potential of these proteins as targets for
biotechnological applications.  Methods used will include 14-3-3 gene
silencing techniques and the establishment of strategies to inhibit
14-3-3 proteins in transgenic plants.  The candidate will work in a lab
whose focus is the role of 14-3-3 proteins and signal transduction in

Project supervisors:
Dr. Michael Roberts - University of York
Dr. Simon Warner - Zeneca Agrochemicals
Dr. Jutta Blank - Zeneca Agrochemicals

The studentship is available from October 1st 1999. Candidates should
have a background in either plant biology, molecular biology,
biochemistry or related areas, and expect to graduate this summer with a
first or upper second class degree.  Applications should be made through
the Biology Graduate School Office.

For further information, contact Dr. Michael Roberts, The Plant
Laboratory, Department of Biology, University of York, PO BOX 373, York,
YO10 5YW.
E-mail: mrr5 at york.ac.uk
Phone: (01904) 434323.

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