THE ISRAEL SCIENCE FOUNDATION Symposioum on:
"Integration of signaling pathways: The role of multiprotein complexes"
November 2-5 1999. Kibbutz Maíagan, Sea of Galilee, Israel
The recent discovery of the COP9 complex, the regulatory lid of the
proteasome, eIF3, and the evolutionary/structural relationships between
these three seemingly distinct complexes has led to the development of a
new field of biology. These three protein complexes are involved
independently in the regulation of transcription, translation and
proteolysis. However, recent evidence suggests that there may be direct
interactions between these three complexes. As developmental regulation
must occur at multiple levels, elucidating the mechanisms of crosstalk
between these and other complexes is of utmost importance.
The study of large protein complexes -ìZomesî - poses unique issues and
difficulties. The goal of this symposium is to bring together
researchers from diverse fields, in order to initiate joint efforts for
studying the functioning of these complexes. This symposium will serve
as an important venue for discussion of the conservation and diversity
of these complexes. As such, the conference will provide general
overviews of each complex as well as other regulatory complexes, such as
TFIID, the splicesosome, and the cyclosome. The conference will also
provide a forum for students to present their recent results. A
roundtable is planned for the end of the conference in order to try to
integrate the diverse data into integrated models.
For more information, see the conference web page at
Or contact me directly. Participation is limited.
chamd at post.tau.ac.il