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Postdoctoral Position

Tue Feb 13 16:38:58 EST 1996


We are interested in RNA editing in plant mitochondria and chloroplasts.  RNA 
editing is a post-transcriptional process that converts cytidines to uridines, 
and consequently changes the amino acid specified by a codon.  As a result, the 
DNA encodes genes with "mistakes" that are corrected post-transcriptionally by 
editing.  My lab is funded for two projects- one project addresses the 
consequences of incomplete editing.  Some populations of transcripts are highly 
heterogeneous as a result of incomplete editing.  We have recently shown (Plant 
Cell 8:107) that both unedited and edited ribosomal protein subunit 12 mRNAs are 
translated, but only the edited translation products assemble into ribosomes.  
The incompletely edited translation products, which have aberrant amino acid 
residues, fail to accumulate as ribosomal subunits and are free in the matrix.  
A second project in the lab addresses mechanistic aspects of the editing 
process.  Funding for a post-doctoral scientist is available through grants from 
the USDA and Human Frontiers Science Program.  Applicants should send their 
resume, statement of research interests, and names and addresses of three 
referees to:

Dr. R. Michael Mulligan
Department of Developmental and Cell Biology
University of California
Irvine, CA  92717
    Located six miles from the ocean in Orange County, UCI is in the center of a 
flourishing high technology and cultural center.  The campus is very strong in 
biomedical research.  We are an equal opportunity employer committed to 
excellence through diversity.  

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