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Ap3-11 mutation

Mulei Nthenge mulei at dartmouth.edu
Fri Aug 2 13:31:43 EST 1996


Ap3-1 is a temperature sensitive missense mutation that substitutes a 
methionine for a lysine residue at the carboxyl end of the K-domain in 
Ap3 gene. Ap3-11 is a suppressor of ap3-1. now, direct sequencing of 
the ORF and most of the introns in ap3-11 show no mutation except the 
original ap3-1 but ap3-11 mutants are closer to wild-type than to 
ap3-1.

does anyone know what's happening here?



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