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postdoctoral position

pikaard at WUSTLB.WUSTL.EDU pikaard at WUSTLB.WUSTL.EDU
Fri Sep 16 11:21:05 EST 1994


Dear colleagues,
	A postdoctoral position is available for two years starting
immediately to study the genetic mechanisms controlling nucleolar
dominance in Brassica amphidiploids. Nucleolar dominance describes the
phenomenon in which the ribosomal RNA genes of only one parent are expressed
in a hybrid genome containing both sets of parental rRNA genes. The
underdominant rRNA genes are subjected to allelic repression and are not
expressed.  Neither the basis for the preferential activation nor the
mechanisms responsible for the selective silencing of one set of genes are
known. The major hypothesis to be tested is that an inequity in enhancer
dosage determines the dominant genes via titration of one or more
transcriptional activator proteins, as suggested by studies in Xenopus.
Enhancer-swap experiments in transgenic plants will provide the first
rigorous test of this hypothesis. The successful candidate will have a
strong background in molecular biology, with experience in tissue culture
techniques and transgenic plant production highly desirable. Experience
in gene expression studies is also highly desirable. Candidates are 
expected to have a reasonable publication record in widely-read journals.
My group studies the regulation of rRNA gene transcription by RNA Polymerase
I in both animals (Xenopus) and plants (Arabidopsis and Brassica), resulting
in papers in Cell, Genes and Development, MCB, EMBO and PNAS.  The intellectual
environment at Washington University is excellent. 
	If interested, please send a CV to:
	Craig Pikaard
	Biology Department, Washington University
	Box 1137, One Brookings Drive
	St. Louis, MO 63130
	FAX: 314-935-4432
	Phone: 314-935-7569
	Internet: pikaard at wustlb.wustl.edu



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