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overlapping 3'-ends of two different mRNAs

Christos Ouzounis ouzounis at embl-heidelberg.de
Sun Oct 16 14:20:46 EST 1994

In article <199410131505.IAA26218 at net.bio.net>, katagiri at FRODO.MGH.HARVARD.EDU (Fumiaki Katagiri) writes:
> Dear netters,
>         I found a case in which two adjacent genes in Arabidopsis
> transcribed in the opposite orientations have a 124-bp overlap at the
> 3'-ends of their mRNAs.  These are the disease resistance gene RPS2 and the
> casein kinase I-like gene on chromosome IV (please see Mindrinos et al.
> (1994) Cell 78, 1089-1099, Fig. 1D).  RPS2 encodes two transcript species
> that have length difference in their 3'-untranslated regions.  The larger
> RPS2 transcript has the overlap with the casein kinase I-like transcript.
> Both mRNAs are attached with poly A following this overlap region.  Does
> anybody know such a case in plants, or in eukaryotes?  If there are such
> cases, are anything known about the function of overlapping sequences
> (regulatory, etc.)?
> Thanks in advance,
> Fumi Katagiri
> Ausubel Lab
> Dept. of Molecular Biology
> Massachusetts General Hospital

The first reference on this subject I am aware of is Spencer et al (1986):
Overlapping transcription units in the dopa carboxylase region of Drosophila.
Nature 322, 279-281.

Christos Ouzounis
EMBL Heidelberg

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