Iuval Clejan wrote:
> I didn't see the word "mitochondrial" anywhere. What page?
p142 left column, five lines from the bottom.
> Supposedly it also occurs in cardiac tissue, but I haven't seen these
> references
Correct; PubMed using "tetraploid cardiac" gives several.
> [higher ploidy] is almost certainly beneficial to some liver functions.
What's your evidence of this?
> I have some reasons to guess (will be posted soon) that nulcear genes
> involved in mitochondrial maintanance (which ones are known?)
Depends what you mean by "maintenance". Do you mean specifically repair
(e.g. of DNA)? Antioxidant enzymes? Lots, anyway.
> are being replicated to give an advantage to the mitochondria of the
> higher ploidy cells. Your comments are desired...
Quite possible. Hagen et al (Proc Natl Acad Sci 94:3064) found that in
old rats the binucleated cells had a bigger mitochondrial proton gradient,
which presumably means they had less mitochondrial membrane damage.
Aubrey de Grey
