I don't know if my previous message went through. Seems like it didn't
(but I don't know for sure since I'm posting through google) so I'll
try again. I want to know if Mn-Cu SOD can be transported in small
but significant quantities into mitochondria, and once there if it can
be catalytically active and protect the membrane from ROS. I'm
interested in the etiology of higher ploidy in liver cells and one
article found that this was weakly inhibited when mice had extra Mn-Cu
genes. Is it possible that the Mn-Cu SOD protected mitochondria? Or is
this more likely a cytosolic effect?
-Iuval
