The process of utilizing stored fat for energy is nicely described in the
book "Role of
Nutrition in Health and Disease" by William Cornatzer, MD, PhD. First, the
stored
triglycerides must be hydrolyzed by a hormone-sensitive lipase to release the
fatty
acid and glycerol. The fatty acids pass out of the adiocyte, combine with
serum
albumin and are transported to tissues like heart and muscle to be
metabolized for
energy. This hormone-sensitive lipase in the adiocyte is the rate-limiting
factor in
adipose tissue metabolism. A number of hormones stimulate this enzyme;
epinephrine, norepinephrine, glucagon, thyroid stimulating hormone and adreno-
corticotropic hormone.
Fatty acids from adipose tissue enter the mitochondria of muscle, heart and
liver with
the help of carnitine, which is synthesized from lysine and methionine. The
beta-oxidation of the fatty acid occurs in the mitochondria of muscle, heart
and liver with
the help of enzymes including FAD (from Vitamin B-2) and NAD (from Vitamin
B-3).
CLA may stimulate the pancreas to release glucagon to start this process.
I have been using a gelcap containing 500 mg of LCFFA (Long Chain FREE Fatty
Acid) to directly stimulate the pancreas to release glucagon and get rid of
body fat.
It is much cheaper than CLA and is probably safer and more effective. Over
four years, the only observed side effect is some depletion of fatty
nutrients such as
Vitamin D, which can be remedied with supplements if needed.
Ralph L. Samson
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