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Support for the Glycation Theory of Aging and the Inhibition Ability of Aminoguanidine

Tom Matthews tmatth at netcom.ca
Mon Sep 20 05:27:07 EST 1999


My friend William who has not been active on these ngs for awhile just
sent me the following:

Mech Ageing Dev 1999 May 17;108(3):239-51 
Advanced glycation in D-galactose induced mouse aging model.
Song X, Bao M, Li D, Li YM
Institute of Medicinal Biotechnology, Chinese Academy of Medical
Sciences, Beijing, People's Republic of China.
 
It was first reported in China that injection of a low dose of
D-galactose into mice could induce changes which resembled accelerated
aging. The aging model shows neurological impairment, decreased activity
of anti-oxidant enzymes, and poor immune responses. However, the
underlining mechanism remains largely unknown. D-galactose is a reducing
sugar that can form advanced glycation endproducts (AGE) in vivo. To
investigate the role of AGE in this aging model, a group of 5-month-old
C57 mice were injected daily with D-galactose, D-galactose modified
AGE-lysine (AGE-lysine), L-glucose, L-lysine, or control buffer for 8
weeks. Two additional groups were treated with the AGE formation
inhibitor, aminoguanidine. The results show that D-galactose, L-glucose,
and AGE-lysine treated mice had a significant increase in serum AGE
levels, memory latency time and error rate, and skin hydroxyproline
content. Similar to aged controls, these mice also had a significant
decrease in motor activity, lymphocyte mitogenesis, interleukin-2 (IL-2)
production, and superoxide dismutase (SOD) enzyme activity. The
aminoguanidine treated D-galactose-injected mice, however, 
showed no significant changes in these parameters in comparison with
young controls. These data indicate that D-galactose and L-glucose form
AGEs in vivo and that elevated AGEs may accelerate the aging process.
The fact that both D-galactose and AGE treated mice resemble aged mice
suggests that advanced glycation, at least partially, accounts for the
mechanism of this aging model. 
PMID: 10405984, UI: 99334485 
 
--Tom 
Tom Matthews
 
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