IUBio

Telomerase deficient mice

James james at ryley.com
Tue Apr 13 00:00:30 EST 1999


> > If this slow growth stage is similar to [human cell] quiescence then the
> > cells would be "normal" both before and after experiencing this slow growth
> > stage and that appears to be the case.
> 
> No.  A simple way to see this is to consider the reversibility of the cells'
> state.  Cells that escape from quiescence on demand, e.g. by removing contact
> inhibition, are indeed normal, but they can also be returned to quiescence
> on demand by restoring contact inhibition.  This is a totally unambiguous
> difference from cells that spontaneously, and irreversibly, escape from
> slow growth.  Cells can also escape spontaneously (and irreversibly) from
> quiescence, of course, but then they're likewise no longer normal.
> 
> Aubrey de Grey

Oops.  Nevermind my last post - I think this means you agree with
me.

James




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