Thermodynamics of aging

Georgi P. Gladyshev academy at ENDEAV.ORG
Fri May 8 03:59:56 EST 1998

To: aging at net.bio.net

From: academy at endeav.org ("Georgi P. Gladyshev")

Subject: thermodynamics and aging, macrothermodynamics 

Date: 8 May,1998

Subject: Aging, Supramolecular chemistry and thermodynamics of
biological evolution, Thermodynamics of origin of life,
Macrothermodynamics, Self-assembly of supramolecular structures,
Supramolecules and Assemblies, Adaptation

Dear Colleagues, 
My Institute: URL http://www.endeav.org/evolut/age/evol.htm 
The information in my URL is: 

Track: Thermodynamics of Ontogenesis and Phylogenesis 
                    The theory is presented in work: G.P.Gladyshev,
               "Thermodynamic Theory of the Evolution of Living Beings".
                           The work has been published by
                     NOVA Sci. Publ., Inc., NY, USA, 1997 - ISBN

                          E-mail: academy at endeav.org
                         Academy of Creative Endeavors,
                     36, Novy Arbat, Moscow, 121205, Russia
                           Professor Georgi P.Gladyshev  

     This work is devoted to the physical theory of the biological
evolution and aging. The theory is based on macrothermodynamics, i.e.,
the hierarchic thermodynamics of complex systems. The results of
the studies presented in the work allow one to state that the
peculiarities of the evolution of living beings, as well as the
peculiarities of the chemical evolution, can be explained without the
concepts of the dynamical self-organization and the dissipative
structures. According to the second law, the tendency of the evolution
of biological systems on chemical and supramolecular levels can be
determined by studying the effect of thermodynamical self-organization
(self-assembly). The criterion for estimating the evolutionary
development of supramolecular structures of biosystems (biotissues) is
given by the variation of the specific Gibbs function of their 
formation. During the processes of ontogenesis, phylogenesis, and
biological evolution in general, the specific supramolecular component
of the Gibbs function of a biosystem, that is quasi-closed
thermodynamically and kinetically, tends to a relative minimum. The
value of this minimum is a characteric of the given biosystem surrounded
by the given environment. The non-stationary theoretical model presented
in the monograph explains the reasons causing the variations in the
chemical composition and structure of living beings in the course of
ontogenesis, phylogenesis, and the evolution in general. It also allows
to find out the rules determining the variations in the composition and
structure of a biosystem during its adaptation to the external
conditions. At present, it seems that the most essential applications of
the theory relate to the study of the living creatures behaviour and to
gerontology, pharmacology, diet, nutrition. The work is written as an
interdisciplinary monograph and is designed for a reader with university
      During the last decades, an opinion has widely spread that there
is "the apparent  contradiction between biological order and laws of
physics - particularly the second law of  thermodynamics". Besides, it
is claimed that this contradiction "cannot be removed as long  as one
tries to understand living systems by the methods of equilibrium
 The author of the present work states: if living systems are described
in the framework of
 hierarchic equilibrium thermodynamics, this contradiction does not

                Review of the work has been published in Journal of
Biological Physics,  Volume 23, issue 2 (June 1997), pp.129-131

  See also: 

     1. G.P.Gladyshev, "Thermodynamic Direction of Biological Evolution:
Model and Reality", Biology      Bulletin, Vol. 23, No. 4, 1996, pp.
315-322. Translated from Izvestia Akademii Nauk, Seriya
     Biologicheskaya, No. 4, 1996, pp. 389-397. 
     2. G.P.Gladyshev, "Thermodynamic Trends in Biological Evolution",
Biology Bulletin. Vol. 22, No. 1.     1995. pp. 1 - 9. Transated from
Izvestiya AN. Seriya Biologicheskaya. No. 1. 1995. pp. 5 -14. Original
     Russian Text Copyright ¿ by Gladyshev. 
     3. G.P.Gladyshev, "Thermodynamics of Aging", Materials for the
Symposium "Termodynamics and      Information Theory in Biology",1998. 
     4. G.P.Gladyshev,"Some Medical Aspects of Thermodynamic Theory of
Evolution",Medical Market, 25      (1, 1997), P. 6-7, Popular article 
     5. G.P.Gladyshev, "Thermodynamics of Aging", Report (AAAS), 1998 
     6. G.P.Gladyshev, Thermodynamic Nature of The Biological Evolution.
The Model and The Reality. In:
     Chemical Evolution: Physics of the Origin and Evolution of Life.
Eds. Julian Chela-Flores and
     F.Raulin. Kluwer Publ. p.221. 1996. 

Additional materials: K.G.Denbigh "Note on Entropy, Disorder and

Please, respond to e-mail: 
academy at endeav.org  or mail: Academy of Creative Endeavors, 36, Novy
Arbat, Moscow, 121205, Russia.

Georgi P. Gladyshev
Professor of Physical Chemistry 
(Institute of Ecological Biophysical Chemistry of the Academy of
Creative Endeavors, 
Laboratory of Thermodynamics and Macrokinetics of Non-equilibrium
Systems of N.N.Semionov Institute of Chemical Physics of the Russian
Academy of Sciences),
Professor of the Chair of Biomedical Systems and Devices
(N.E.Bauman Moscow State Technical University, 1975-1985)

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