You could also experiment with the use of potent synthetic anti-oxidants;
BHT
BHA
Copper Salisillac acid
NDGA
Santoquin
Although the other ideas posted are also quite interesting, especially the MICA
binding process
Rodney Reid wrote:
> Vladimir V. Bakaev (vlad at bakaev.nsk.ru) wrote:
> : I'm looking for any scientific extraordinarily unusual ideas and methods
> : for prolonging life-span. I'm going to investigate these ideas and methods
> : on the nematode Caenorhabditis elegans. Any suggestions?
> : Thanks,
> : Bakaev V.V.
> : RUSSIA, 630107, Novosibirsk, box 45
> : e-mail: vlad at bakaev.nsk.ru>> Subject: Re: news ideas
> Newsgroups: bionet.molbio.ageing
> References: <6d7v1c$o0c at mserv1.dl.ac.uk>
> Organization: Exec-PC Internet
> Distribution: bionet
>> Hi Vladimir,
>> Sounds interesting. Here are number of unusual ways of
> (possibly) prolonging lifespan that haven't been fully investigated, which
> I will explain below:
>> (1) RNA/DNA (nucleic acid) supplementation
> (2) Increasing length of circadian cycle
> (3) Mica binding to DNA, as a protectant?
> (4) Chinese patent formula "ren-shen-yang-rong-tang"
>> (1) Nucleic acid supplementation
>> Here's a study that seems really interesting, and as far as I know has
> never been attempted again:
>> Odens, Max. Prolongation of the life span in rats. Journal of the American
> Geriatrics Society. 21(10): 450-451. October 1973.
>> "To test the effect of RNA-DNA in preventing the deleterious effects of
> old age, an experiment was conducted that involved 10 rats with a normal
> life span of 800-900 days. All were fed the same diet; 5 rats were not
> treated, and 5 were given weekly injections of DNA + RNA. After twelve
> weeks the difference in appearance, weight and alertness was remarkable.
> The 5 untreated rats died before 900 days. Of the treated rats, 4 died at
> ages of 1600-1900 days, and 1 at 2250 days. A parallel cannot be drawn
> with aging in human beings fed RNA-DNA, but the findings on rats may have
> some application to cellular studies on cancer."
>> ...You may want to link to the longevity digest's old topics page at:
>http://www.interchange.ubc.ca/browley/archive.html>> (2) Increasing length of circadian cycle
>> This is just a hunch, but since it seemed to hasten death in rats when a
> short seasonal cycle was used. Possibly a longer day night (with maybe
> artificial seasonal influences in temp, lux, sunrise/sunset times, etc.)
> would trick the nematodes growth cycle? Sorry I can't find the rat
> study for you.
>> (3) DNA to Mica binding as a protectant of DNA(?)
>> Another hunch. Chemically modified mica has been mentioned again and
> again in ancient Chinese, Indian, and Tibetan medical texts as a longevity
> agent. Research from the early 1990s started coming out that Mica could
> bind tight enough to DNA to allow it to be imaged with scanning tunneling
> microscopes, and the addition of certain metal ions to the mix stopped the
> supercoiling that was happening when bonding with just straight Mica.
> Here's a link to dejanews to an article I wrote a while back on this,
> although to my knowledge no one has scientifically tried this on living
> cells yet: http://x3.dejanews.com/getdoc.xp?AN=217970037>> See if you can get your hands on any traditional formulas of mica, either
> Indian ("Abhrak Bhasma") or Tibetan. Likely there are going to be hugely
> expensive, as the traditional texts call for years of daily preparation
> before it's ready for use. Try finding an address for the newly opened
> Astro-Medical Centre, Lhasa, Tibet and ask them about it.
>> (4) Chinese patent formula "ren-shen-yang-rong-tang"
>> Now that I think about it, most of the Japanese done research (their name
> for it is Ninjinyoeito) shows this collection of herbs to increase
> lifespan in Werner's Syndrome skin cells which wouldn't affect nematodes
> as they don't have dividing cells once they hit adulthood right? See:
>> Am J Chin Med 1992;20(3-4):295-305
> The effect of Ninjinyoeito on Werner's syndrome skin fibroblasts.
> Uchiyama Y, Nakajima S, Ohno T, Goto M, Kan M, Haruki E
>> "The effect of Ninjinyoeito on three cases of Werner's syndrome
> fibroblasts was investigated. In all three cases, groups which were
> treated with Ninjinyoeito showed improved life-span doubling levels
> compared to groups which were not treated with Ninjinyoeito. Also, all of
> the treated group in all three cases showed significantly higher values in
> the rates of DNA synthesis including two cases which showed significantly
> higher rates of protein synthesis."
>> Please let us know about your research results.
>> ...Rodney
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