Hi spring,
Would telomerase have any effect on non-dividing cells, which (I'm
assuming C.elegans cells at adulthood are non-dividing)? I would think
that telomerase would also have no impact on fruit flys either.
It seems that the trick with C.elegans (and drosphilia) is keeping
the adult non-dividing cells from going into apotosis? Right now pumping
up antioxidants, either by gene modification or providing external sources
of antioxidants, and energy restriction (heat, calorie, light) seem to be
the only way to lengthen lifespan....and these have already been tried in
hundreds of combinations.
Maybe their movement can be restricted? Seems to work with fruit
flys (initially grounded ones live longer)
...Rodney
spring (spring at jumpnet.com) wrote:
: Vladimir V. Bakaev wrote:
: >
: > I'm looking for any scientific extraordinarily unusual ideas and methods
: > for prolonging life-span. I'm going to investigate these ideas and methods
: > on the nematode Caenorhabditis elegans. Any suggestions?
: > Thanks,
: > Bakaev V.V.
: > RUSSIA, 630107, Novosibirsk, box 45
: > e-mail: vlad at bakaev.nsk.ruThe obvious thing to do is to figure out a way of getting telomerase
: into your worm. How is gene therapy usually done? The gene is already
: known, and it should be possible to clone it (this has been done for the
: human telomerase coding gene, I'm not sure about C. elegans). I think
: the folks at Geron are working on this...And probably reading the little
: that is posted to this NG.
