Excelife excelife at earthlink.net
Fri Jul 24 09:06:18 EST 1998

In article <bxKt1YDFGGRe092yn at istar.ca>, gnome at istar.ca says...
>In article <6ovdse$29q$1 at fir.prod.itd.earthlink.net>,
>excelife at earthlink.net (Excelife) wrote:
>>Unfortunately, Advanced Tissue Sciences, Inc is as bad as Genzyme Corp.  To 
>>quote their website "Advanced Tissue Sciences is a tissue engineering 
>>utilyzing its PROPRIATARY core technology to develop and manufacture human 
>>tissue products..." (emphasis added).  I did a Medline search, a periodical 
>>search and a BioMedNet search and could't find anything published by this 
>I've seen nothing to indicate that these companies are not in full
>compliance with the law.  You seem to have a political axe to grind
>with the system of patents we have, and to that end you are
>demonizing these companies.
>Check http://www.advancedtissue.com/bibliography.htm for their
>research papers.

Thank you, again, for your professional and well researched response.

I re-reviewed most of the abstracts of their researchers cited in the 
biliography and stand by my conclusion that they have published nothing in 
regards to tissue regeneration.  Their product, Dermagraft-TC, apparently is 
headed toward FDA approval and it could be of help to burm victims if their 
process turns out to be cost effective. Their research papers reflect these 
efforts and I hope they're successful.

The question they don't appear to answer in any of their research papers is 
how do they get these human fibroblasts to live beyond their "Hayflick 
Limit"?  If human cells, dermal, epidermal or otherwise could just grow on a 
matrix of synthetic fibers this would have been done years ago.

Other "published" research seems to suggest that transforming growth factor 
beta2 has an effect on cellular communication and age related genetic 
expression.  Some of these effects have the result of neo-natal skin cells 
failing to differentiate and continuing to reproduce for an extended period 
during this stage.

Advanced Tissue Sciences, Genzyme and a number of other companies are 
expanding on these and other results to develop their "propriatary" processes 
to develop a patentable end product.  By keeping the results of this 
underlying research secret, these companies are hindering the research into 

I may be "demonizing" these companies but they are "killing" us!  Each day 
they refuse to share information on processes that have a direct relation to
cellular aging is a days delay in the research into longevity.  How many days 
do you have left? 

Thomas Mahoney, Pres.
Lifeline Laboratories, Inc.

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